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Dr. Mark Olfson said that recognizing a younger person’s distress, talking about those feelings, and guiding him or her to professional help quickly can save a life and get a Gen Zer back on track.
The trial did not replicate the improvements in Mullen scores and in adaptive behavior that “led most people to be excited about the original paper,” says Dr. Jeremy Veenstra-VanderWeele.
“In addition to a more granular conceptualization of anhedonia, future studies would greatly benefit from assessment of anhedonic behavior in daily life,” writes Dr. Randy P. Auerbach and colleagues.
Products might not contain the amount of CBD that is advertised, and might even contain undesirable ingredients, such as THC, Dr. Margaret Haney says.
"As far as prevention goes, the beneficial effect of ramelteon looks pretty strong, but the amount of evidence for its efficacy is actually pretty low," Dr. Peter Shapiro said.
Dr. Jeffrey Lieberman’s concerns about whether dosing strategies for ketamine have been properly set by clinical trials are mentioned in this Q&A.
Dr. Paul S. Appelbaum and colleague examine the multiple changes looming in both the doctor’s and the patient’s roles in the move toward precision medicine.
“Going from not knowing each other to identifying shared interests is one of the first steps in making new friends and apps, online communities, the internet can fast track that,” Dr. Ali Mattu said.
When the drug works, its effect is almost immediate. That speed “is a huge thing because depressed patients are very disabled and suffer enormously,” said Dr. John Mann.
Dr. Alan S. Brown, said that "overall, the investigators have done a commendable job." However, he also noted that the "findings could also be influenced by treatment-seeking behaviors."