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“... certain personality traits and the presence of other psychiatric disorders may confer added risk to a range of other problems, like criminal activity,” said Dr. Deborah Glasofer.

“While depression may be a genetic disorder, a parent’s illness has a very strong environmental effect on her child," said Dr. Myrna Weissman.

Over the past decade, clinical depression is up among American adolescents and young adults. Dr. Mark Olfson joins the discussion.

According to Dr. Carl Hart, the failure to acknowledge the pleasurable dimension of why we take drugs is a serious problem, with serious consequences.