Cannabis, Youth, Safety, and Effectiveness Research Group

Principal Investigator
The world’s approach to cannabis is changing rapidly – from medical cannabis programs to full recreational legalization – and this research group aims to ensure these changes prioritize public health and safety. Led by Dr. Sultan, the Columbia Research Group on Cannabis, Youth, Safety & Effectiveness focuses on the implications of today’s high-potency, widely available cannabis, especially for young people’s mental health. Leveraging backgrounds in psychiatry, epidemiology, public health, and chemistry, the lab takes a 360° view of the contemporary cannabis environment. A core concern is that as society increasingly views cannabis as “benign” or even medicinal, we must rigorously study the actual outcomes in youth who use it. Dr. Sultan’s recent research has sounded the alarm: a Columbia study found that even casual, non-disordered cannabis use is linked to significantly higher risks of depression and suicidality in teenagers. Teens who use cannabis recreationally are 2–4 times as likely to develop psychiatric disorders (like depression) than those who abstain. Such findings underscore why this lab exists – to provide scientific evidence on cannabis safety and effectiveness, informing policymakers, clinicians, and families in an era of legalization.
Areas of Expertise
Adolescent Substance Use
The lab is led by child & adolescent psychiatrists with training in adolescent addiction and prior research on contemporary cannabis and vaping, our team bridges a developmentally informed clinical perspective to understanding the impacts of cannabis on public health.
Large Data Sets Analysis
Our team has experience utilizing large nationally representative data sets, such as Monitoring the Future (MTF), the National Study on Drug Use and Health (NSDUH), and Adolescent Brain and Cognitive Development (ABCD). By analyzing these datasets, they track patterns in teen cannabis use, perceptions of harm, and associated outcomes over time. This “macro” approach complements the lab’s on-the-ground studies, painting a comprehensive picture of cannabis’s impact.
Cannabis Chemical Analysis
Uniquely, the lab collaborates closely with organic chemists at Columbia, enabling state-of-the-art chemical analysis of cannabis products. This means the team doesn’t just rely on surveys – they test the products youth are using. By analyzing THC potency, contaminants, and cannabinoid profiles, they address public mental health concerns from a toxicological angle. For example, lab scientists can verify if a product’s label (Certificate of Analysis) is accurate or detect dangerous additives. This interdisciplinary prowess allows the group to connect chemical data with health data – essential in an era of high-potency concentrates and novel cannabis compounds.
Current Projects
Cannabis Access and Safety in New York (CASNY)
Following New York State’s legalization of recreational cannabis, the lab launched a multifaceted project examining how legalization affects youth. In one eye-opening “secret shopper” study, a young research assistant (age 22, posing as underage) visited cannabis retailers across NYC to audit their practices. The findings were stark: unlicensed cannabis shops frequently failed to check ID (only ~10% did), whereas all licensed dispensaries enforced age verification. Unlicensed stores often sold cheaper, highly potent products and even used youth-friendly marketing (cartoon logos, candy displays). The lab also compared product labeling and quality: licensed outlets generally complied with state regulations by posting potency and safety certificates, unlike most unlicensed outlets. Additionally, the team’s chemists collected vape cartridges and edibles to test for contaminants and verify THC levels, assessing whether unregulated products pose greater health risks. CASNY thus provides a data-driven look at legalization’s aftermath – revealing gaps (like easy youth access in the gray market) that need to be addressed for safe cannabis use. These results have been shared with policymakers, highlighting the need to crack down on unlicensed “cannabis stores” and enforce age restrictions.
Clinician Guidance for Contemporary Cannabis
Another key project aims to inform doctors and mental health providers about today’s cannabis. The landscape of cannabis products (from high-THC concentrates to edibles with delayed effects) is very different than decades past, and many clinicians are unsure how to counsel youth who use these products. The lab is surveying pediatricians, psychiatrists, and addiction specialists to identify what knowledge gaps exist. They are also synthesizing research on issues like Cannabis Hyperemesis Syndrome (a severe cyclic vomiting condition seen with heavy use) and the mental health effects of ultra-potent THC formulations. By understanding what frontline clinicians know and don’t know, Dr. Sultan’s group will develop educational materials or guidelines to help evaluate and treat young people using today’s cannabis. For example, initial work suggests many pediatricians are unaware that even non-addicted, casual cannabis use can double teens’ risk of adverse outcomes. The lab is preparing briefs and workshops to translate findings (like those on subclinical use harms) into practical advice for clinical care. The ultimate goal is to equip healthcare providers with evidence-based practices for screening, advising, and treating youth in this new era of widespread cannabis use.
Grants & Funding
Recently, it received generous philanthropic support from the Koudijs Family, enabling the expansion of research on cannabis product safety and youth prevention programs. The lab is grateful for such support, which underscores community concern about keeping kids safe amid legalization.
Resources
News
- ‘Behind the 8 Ball:’ How Research is Trying to Catch Up on Cannabis and Kids
March 27, 2024
The 74 - Cannabis Use Is on the Rise in the US – Except Among Younger Teens
December 11, 2023
New Scientist - Is Cannabis Bad for Teens? Data Paint a Conflicting Picture
December 11, 2023
Scientific American - Pot Use Linked to Depression, and Other Science News
Fall, 2023
Columbia Magazine - Why We Know So Little About Cannabis – and Why Scientists Are Worried
October 23, 2023
Scientific American - Columbia Study: Casual Cannabis Use Greatly Increases Teens’ Risk of Depression, Suicidality
July 20, 2023
SciTechDaily - Recreational Cannabis Use By Teens Linked to Risk of Depression, Suicidality
May 5, 2023
Columbia University Department of Psychiatry - Marijuana Linked to Mental Health Risks in Young Adults, Growing Evidence Shows
May 26, 2023
NBC News
Podcasts
- Blunt Truths on Marijuana
May 3, 2024
Really? no, Really? Podcast - Cannabis and Teen Mental Health: What Teens Need Know
Apr 19, 2024
Healthy Teen Life, Podbean - Podcast #920: Is Cannabis a Safe Drug?
August 21, 2023
The Art of Manliness Podcast
Regulation Information
Videos
- Substance Abuse in Teens: What’s Happening on the Ground, What Parents & Pediatricians Need to Know
October 9, 2024
Columbia Children's Health - EP 65 Bonus Episode: Kicking Pot Cold Turkey | Really? no, Really?
May 3, 2024
Really? no, Really? Podcast - Baking Young Minds: Scientific Concerns for Cannabis on Kids
June 27, 2023
Pioneer Institute
Lab Members
Select Publications
Sultan RS, Zhang AW, Olfson M, Kwizera MH, Levin FR. Nondisordered Cannabis Use Among US Adolescents. JAMA Netw Open. 2023;6(5):e2311294. Published 2023 May 1. doi: 10.1001/jamanetworkopen.2023.11294
Becker TD, Olfson M, Menzi PJ, et al. Cannabis Access by Retailer Type in New York. Pediatrics. 2025;155(3):e2024068669. doi: 10.1542/peds.2024-068669
Olfson, M. Wall M. Shang-Min L. Sultan R.S. Blanco C. E-cigarette Use Among Young Adults in the U.S. Am J Prev Med. 2019 Mar 16. pii: S0749-3797(19)30024-8. doi: 10.1016/j.amepre.2018.12.004



