R01MH114965 (PI: Horga; 07/01/2018-06/30/2023), “Deficient Belief Updating as a Convergent Computational Mechanism of Psychosis”
The goal of this project is to study belief updating in patients with schizophrenia using fMRI and computational modeling.
R01MH117323 (PI: Horga; 07/01/2018-06/30/2023), “Individualized risk prediction in persons at clinical high-risk for psychosis using neuromelanin-sensitive MRI”
This project aims to identify risk factors of conversion to psychosis using MRI and clinical interviews.
R01MH129395 (PI: Horga; 2022-2027), "An integrative computational interrogation of circuit dysfunction in schizophrenia via neural timescales"
This project aims to combine genetic, developmental, fMRI, neurocognitive, and self-report data across several large-scale datasets to provide an integrated framework for the convergent pathophysiological mechanisms linking the complex genotypes to neural and behavioral phenotypes associated with the illness.
NYSPI Chairman’s Collaborative Pilot Award (PI: Horga), “Decoded fMRI neurofeedback for auditory hallucinations: a novel mechanistic and therapeutic tool targeting hallucination-related activation patterns”
The study aims to implement a novel fMRI decoded neurofeedback (DecNef) to understand the relationship between auditory hallucinations and activation patterns in the auditory cortex in schizophrenia, and to test its potential for ameliorating this symptom.
NIMH K23 MH101673 (PI: Horga; 6/21/14 - 3/31/19), “Neural mechanisms of sensory predictions in schizophrenia with hallucinations”.
The goal of this project is to study mechanisms of sensory learning in relation to auditory hallucinations in schizophrenia using fMRI and computational modeling.
David Mahoney Neuroimaging Grant Program (PI: Horga; 9/17/15 - 9/16/18), “Neuromelanin-sensitive MRI: development and validation of a novel dopamine biomarker for risk of schizophrenia and Parkinson’s disease”.
The goal of this project is to use MRI scans to develop, validate, and identify a novel dopamine biomarker for risk of schizophrenia and Parkinson’s disease.
NIMH R21 MH110700 (PIs: Girgis and Horga; 9/1/16 - 8/31/18), “Sensory-learning deficits and conversion to psychosis among individuals at clinical high-risk: a longitudinal model-based fMRI study".
In this project we will use functional magnetic resonance imaging (fMRI) to examine the neurobiological mechanisms involved in the development of hallucinations and other psychotic symptoms in a population of clinical high risk for psychotic disorders.
NIMH R01 MH109635 (PI: Abi-Dargham [Stony Brook University], Co-I: Horga; 9/16/16 - 6/30/21), “Neurobiological correlates of auditory processing in health and disease: an RDoC study”.
This project will use a multidisciplinary approach (including PET, model-based fMRI, and MRS) to identify molecular and neural correlates of auditory perceptual disturbances in health and across traditional (DSM-IV and DSM-V) disease categories, in line with the NIMH’s RDoC initiative.