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The clinical data supporting the effectiveness of brexanolone in helping women recover from postpartum depression sheds new light on the neurobiology of the illness, said Dr. Catherine Monk.

“The major thing is, of course, the rapid effect,” said Dr. Margaret Spinelli,

“The advent of these digital pills introduces a myriad of ethical quandaries,” writes Dr. Robert Klitzman.

The trial did not replicate the improvements in Mullen scores and in adaptive behavior that “led most people to be excited about the original paper,” says Dr. Jeremy Veenstra-VanderWeele.