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Dr. Paul S. Appelbaum and colleague examine the multiple changes looming in both the doctor’s and the patient’s roles in the move toward precision medicine.

“Approval of esketamine is important for patients because other options like transcranial magnetic stimulation work more poorly in medication-resistant depression,” writes Dr. J. John Mann. .

When the drug works, its effect is almost immediate. That speed “is a huge thing because depressed patients are very disabled and suffer enormously,” said Dr. John Mann.

The test could give parents false hope about quick answers for their child’s diagnosis — and, in doing so, prolong their path to the right answer, Dr. Jeremy Veenstra-VanderWeele says.