Current Studies

  • Principal Investigator

    J. John Mann, MD
    This research study uses brain imaging to explore the biological causes of depression andsuicidal behavior. We hope to develop a better understanding of how people who attempt suicidediffer from those who dont in order to improve prevention. Participation includes brain imagingscans (MRI and PET), neuropsychological tasks and clinical assessment. Eligible individualswill be compensated up to $475. To minimize the risk of COVID-19 exposure, we conduct allscreening and eligibility interviews remotely.
  • Principal Investigator

    J. John Mann, MD
    This research study uses brain imaging to explore the biological causes of major depression andwhy some people feel suicidal or may act on such thoughts. We hope to develop a betterunderstanding of how people who feel depressed and suicidal cope with their feelings so we canimprove treatment and prevention. You may qualify if you have depression with or withoutsuicidal thoughts or any history of suicide attempts. Participation involves a detailed diagnosticset of interviews, brain imaging scans (MRI and PET) and neuropsychological tasks.
  • Principal Investigator

    Jeffrey M. Miller, MD
    Do you suffer from depression? Have standard treatments not been helpful? Researchers at Columbia University Irving Medical Center are conducting a study of an experimental antidepressant called ketamine, which can provide rapid relief of depressive symptoms in some patients. The study involves an inpatient stay, during which participants undergo brain imaging before and after ketamine treatment, and receive 4 intravenous infusions of ketamine over two weeks.
  • Principal Investigator

    Francesca Zanderigo, PhD
    Note: Due to COVID-19, all the research procedures, except the phone screening for this study, has been on pause. The in-person screening and the research procedures will start after the pause is lifted. The purpose of this study is to examine the use of a new portable brain imaging device to study a measure of brain activity, and to develop optimal methods for analyzing the data from this device.
  • Principal Investigator

    Jeffrey M. Miller, MD
    The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS. Previous studies using tDCS have shown that it is helpful in treating conditions like depression and chronic pain. tDCS is administered using two small electrodes that are applied to the scalp.
  • Principal Investigator

    Jeffrey M. Miller, MD
    The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS. Previous studies using tDCS have shown that it is helpful in treating conditions like depression and chronic pain. tDCS is administered using two small electrodes that are applied to the scalp.
  • Principal Investigator

    Jeffrey M. Miller, MD
    The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS. Previous studies using tDCS have shown that it is helpful in treating conditions like depression and chronic pain. tDCS is administered using two small electrodes that are applied to the scalp.
  • Principal Investigator

    Barbara H. Stanley, PhD
    This study conducts behavioral tasks to explore the biological causes of depression and suicidalbehavior. Our ultimate goal is to improve prevention of suicide. Participants will have depression with or without suicidal thoughts or previous suicide attempts. Participation involves clinical assessments, a week-long phone survey, a stress test and computer games. Eligible individuals will be compensated up to $125 and will receive up to 3 months of free doctor visits for medication-based treatment.
  • Principal Investigator

    Barbara H. Stanley, PhD
    This research study conducts behavioral tasks to explore the biological causes of depression and suicidal behavior. Our ultimate goal is to improve prevention of suicide. Participation in this study include clinical assessments, a week-long phone survey, a stress test and a computer game. Eligible individuals will be compensated up to $125. To minimize the risk of COVID-19 exposure, we conduct all screening and eligibility interviews remotely. For in-person procedures, we follow rigorous guidelines to reduce infection risk and promote safety for our participants.