Helen Blair Simpson, MD, PhD
- Professor of Psychiatry at CUMC
On the web

Overview
Helen Blair Simpson, M.D., Ph.D., is Director of the Center for the Obsessive-Compulsive and Related Disorders at the New York State Psychiatric Institute (NYSPI) and Professor of Psychiatry in the Department of Psychiatry at Columbia University Irving Medical College (CUIMC). A physician-scientist who has been funded by the National Institute of Mental Health since 1999, Dr. Simpson uses clinical trials to identify the best treatments for obsessive-compulsive disorder (OCD), collaborates with neuroscientists to elucidate how the brain produces anxiety, obsessions, and compulsions, and partners with implementation scientists to increase access to evidence-based OCD treatment across New York State. Her goal is to transform care for individuals with OCD. Past advisor to the World Health Organization on the classification of OCD and author of the American Psychiatric Association’s Practice Guidelines for OCD, Dr. Simpson currently serves as Associate Editor of JAMA-Psychiatry and the President of the Anxiety and Depression Association of America.
Dr. Simpson graduated from Yale College with a BS in biology. She then completed the MD-PhD program at The Rockefeller University/Cornell University Medical College. Her PhD focused on the brain pathways underlying learned versus unlearned vocalizations in songbirds. She then completed the internship and residency in psychiatry at the Columbia-Presbyterian Medical Center/New York State Psychiatric Institute and a research fellowship funded by the National Institute of Mental Health, before developing the independent research program that she leads today.
Academic Appointments
- Professor of Psychiatry at CUMC
Administrative Titles
- Director, Translational Therapeutics Program, New York State Psychiatric Institute, New York NY
- Co-Researcher Director, The Youth Anxiety Center, NY-Presbyterian Hospital, New York NY
- Director, Center for Obsessive-Compulsive & Related Disorders, New York State Psychiatric Institute, New York NY
Gender
- Female
Credentials & Experience
Education & Training
- MD-PhD, Rockefeller University / Cornell University Medical College
- BS, Biology, Yale College
- Residency: Psychiatry, New York State Psychiatric Institute
- Fellowship: Psychiatry, New York State Psychiatric Institute
Research
My research program seeks to transform our understanding of and treatments for anxiety and obsessive-compulsive disorder (OCD). My long-term goal is to determine what causes symptoms like anxiety, obsessions and compulsions and to identify novel brain targets for treatment development.
My overall approach is to conduct bi-directional translational research: to use insights from basic and cognitive neuroscience to design studies in patient populations and to use insights from human studies to help guide future animal studies. In addition to my basic science and imaging collaborators, my research team includes research psychiatrists, doctoral level scientists, and research staff in the Anxiety Disorders Clinic and the Center for OCD and Related Disorders in the Department of Psychiatry at Columbia University/New York State Psychiatric Institute, both of which I direct. My work is supported by NIMH grants, foundations, and philanthropy.
Research Interests
- Anxiety Disorders
- OCD
Clinical Trials
For the patients of today, I conduct clinical trials to determine how best to deliver our current treatments and to test novel treatments. For the patients of tomorrow, I partner with cognitive neuroscientists, experts in neuroimaging (including positron emission tomography, task-based functional magnetic resonance imaging, and magnetic resonance spectroscopy), and basic scientists to study the brain mechanisms underlying psychopathology.
Selected Publications
- Simpson HB, Foa EB, Liebowitz MR, Huppert JD, Cahill S, Maher MJ, McLean CP, Bender J, Marcus SM, Williams MT, Waver J, Vermes D, Van Meter PE, Rodriguez CI, Powers M, Pinto A, Imms P, Hahn C, Campeas R: Cognitive-behavioral therapy vs risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: A randomized clinical trial. JAMA Psychiatry 2013; 70(11): 1190-9.
- Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K, Gordon JA, Hen R: Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 2013; 340(6137): 1234-9.
- Pinto A, Steinglass JE, Greene AL, Weber EU, Simpson HB: Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder. Biological Psychiatry 2014; 75(8): 653-659.
- Marsh R, Tau GZ, Wang Z, Huo Y, Liu G, Hao X, Packard MJ, Peterson BS, Simpson HB: Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder. American Journal of Psychiatry 2015; 172(4): 383-392.
- The ENIGMA-OCD Working Group (of which Dr. Helen Blair Simpson is a member): Distinct subcortical volume alterations in pediatric and adult OCD: A worldwide meta- and mega-analysis. The American Journal of Psychiatry (in press).
For a complete list of publications, please visit PubMed.gov