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"Some medications can cause undesirable side effects such as emotional dulling," says Dr. David Hellerstein. "Switching or augmenting with more activating medications can address that issue."

90% of people who die by suicide experience some kind of mental illness. Dr. John Mann, said that many of those patients go without help in the US because they can't afford care or don't seek it out.

“Very few PCPs are comfortable managing more serious conditions," says Dr. Mark Olfson. "In rural areas of the country. . .people with these conditions are at real risk.”

Whether medical marijuana is an effective alternative to opioids for pain is still an open question, said Dr. Ziva Cooper.