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There are a number of factors — temperament, personality traits, self-esteem, genes, and family history, to name a few — involved in the etiology of clinical depression, says Dr. Myrna Weissman.

Dr. J. John Mann discusses on this video the "extremely alarming" suicide rate in the U.S., especially among youth.

“Although the number of suicides that occur in clusters may be relatively small, they represent a class of suicides that may be particularly preventable,” said Dr. Madelyn Gould.

Dr. Mark Olfson found that people who take the more than 200 common medications sold in the U.S. that include depression as a potential side effect are, in fact, more likely to be depressed.