Cognitive Development & Neuroimaging Laboratory

Principal Investigator

  • Profile Headshot
    • Director of MRI Research at New York State Psychiatric Institute, New York NY

The Cognitive Development & Neuroimaging Laboratory (CDNL), also known as the Marsh Lab, conducts research projects that focus on understanding the neurodevelopmental trajectories of psychiatric disorders that arise during childhood and adolescence. We use multimodal magnetic resonance imaging (MRI) to study the functioning and structure of neural circuits that support the capacity to self-regulate one’s thoughts, actions, and urges, and the circuits that support learning and memory. CDNL conduct studies aimed at assessing the neurodevelopment of these circuits in healthy children and adolescents and in adolescents with eating disorders. We also assess circuit-based changes following treatment in children, adolescents, and adults with obsessive-compulsive disorder.

Lab Members

Faculty

  • David Pagliaccio, PhD (He, Him)

    • Assistant Professor of Clinical Neurobiology (in Psychiatry)

    Dr. David Pagliaccio received his PhD in neuroscience from Washington University in St. Louis. His graduate work with Drs. Deanna Barch and Joan Luby focused on the effects of stress and stress-system genes on brain structure and function in children with early-onset depression. During his postdoctoral fellowship with Drs. Daniel Pine and Ellen Leibenluft, Dr. Pagliaccio continued fMRI research to examine the neural underpinnings of pediatric anxiety and irritability. His research aims are to use neuroimaging and other methods to understand the mechanisms underlying psychiatric disorders in youth, particularly affective psychopathology, as well as to assess the psychometrics and reliability of currently used research methods. With his collaborators at the Columbia University Irving Medical Center/New York State Psychiatric Institute, Dr. Pagliaccio is exploring alterations in brain circuitry and functioning relating to affective disorders, OCD, learning disorders, and other pediatric pathologies.

  • Xiaofu He, PhD (He, Him)

    • Assistant Professor of Clinical Neurobiology

    Dr. He received his PhD in pattern recognition and intelligent systems from Shanghai Jiao Tong University. During his graduate studies, he was trained in the research of image processing and pattern recognition with a focus on biometrics. During his postdoctoral training, Dr. He developed expertise in brain imaging, including structural MRI, functional MRI (fMRI), and, particularly, diffusion tensor imaging (DTI). One of Dr. He’s long-term goals is to bring together his expertise in image processing, pattern recognition, computational modeling, and neuroimaging to the challenge of understanding the developing brain, leading to more reliable findings in the important area of clinically oriented neuroimaging research and to better understand the mechanisms of depression and other psychiatric disorders.

Staff

  • Kate Durham, PhD (She, Her)

    • Clinical Psychologist

    Dr. Katherine Durham graduated with a bachelor’s degree in psychology from the University of Colorado at Boulder before completing her Ph.D. in School Psychology at Columbia’s Teachers College. She also earned her master’s degrees in Clinical Psychology and Applied Statistics from Teachers College, both of which facilitated her research on posttraumatic stress symptoms and cognitive functioning in children and adolescents. Dr. Durham is interested in research on treatments for various psychopathology among youth. She is currently providing diagnostic evaluations and evidence-based psychotherapy to children and adolescents as part of ongoing research in the lab.

  • Marilyn Cyr, PhD, PsyD (She, Her)

    • Research Scientist II

    Dr. Marilyn Cyr received a PhD in experimental psychology & neuroscience and a PsyD in clinical psychology from University of Quebec at Montreal. Her doctoral work focused on the neural and behavioral mechanisms of central cholinergic systems known to be affected in several psychiatric and neurological disorders. Her postdoctoral work in Dr. Marsh’s lab has focused on brain circuits that support control, reward and learning processes in adolescents with Bulimia Nervosa and other populations with compulsive behaviors, and how these circuits develop in relations with symptoms and symptom changes over time. Her overarching career goal is to uncover the cognitive and neural mechanisms underlying the development of healthy and maladaptive behaviors, with the ultimate purpose of identifying targets to guide early prevention and treatment strategies via cognitive-behavioral and circuit-based interventions.

  • Martine Fontaine, MA (She, Her)

    • Lab Manager

    Martine graduated from Paul Valéry University of Montpellier with a BS in Clinical Psychology and earned a master’s degree in Social-Organizational Psychology at Teachers College Columbia University. She began volunteering for Dr. Marsh in 2011 and learned neuroimaging techniques. She was then hired as a research assistant and was responsible for project coordination, data organization and collection, and data quality assurance. During that time Martine developed clinical and technical expertise in acquiring imaging data from participants with anxiety disorders. In 2018, she was promoted to her current position as Lab Manager. She has since been supervising the lab’s operations across three research projects. Additionally, she oversees talent acquisition processes in the lab, from screening and interviewing applicants to training and mentoring new hires. As a supervisor, she also fosters organizational changes through developing training material, implementing career development initiatives, and promoting diversity, equity, inclusion strategies. 

  • Charlotte Quincoses, BA (They, Them)

    • Research Assistant

    Charlotte graduated from Barnard College in 2018 with a BA in Psychology, focused on child psychopathology. In their previous position, they were Supervisor for the Hepatitis C program at Montefiore Medical Center's Division of Substance Use. Currently, Charlotte is the study coordinator for the MRI portion of the COVID-19 Mother and Infant Outcomes (COMBO) Study. They hope to get a PhD in clinical psychology focused on the dissemination and implantation of evidenced-based treatments into low socioeconomic communities.

  • Sarah Pieper, BA (She, Her)

    • Research Assistant

    Sarah graduated from Smith College in 2018 with a BA in psychology and a minor in education and child study. She has worked with children with developmental disorders in the past and, while at Smith, she worked in a research lab focused on child language acquisition. Those experiences clarified her desire to work in research involving children and their mental health. She is interested in research that investigates the mechanisms of psychiatric disorders and how to effectively treat them in children and adolescents. Her current role at Dr. Marsh’s lab involves coordinating pediatric fMRI studies and clinical trials that examine the neural underpinnings of OCD and anxiety. Sarah is involved in the collection, processing, and analysis of both neuroimaging and clinical data. She plans to pursue a PhD in clinical psychology in the future.

  • Sydney Taylor, BS (She, Her)

    • Research Assistant

    Sydney graduated Magna Cum Laude from Fordham University with a double major in Psychology and Sociology. She previously worked as a Research Assistant in Dr. Amy Roy’s Pediatric Emotional Regulation Lab at Fordham University on a longitudinal study focused on Severe Temper Outbursts (STOs) in children and adolescents. Before joining the Cognitive Development and Neuroimaging Laboratory Team, she worked in investor relations at a NYC based IR and PR firm that worked primarily with biotechnology and biomedical device development. Within Dr. Marsh’s Cognitive Development and Neuroimaging Laboratory, Sydney works as the Project Coordinator for the Inhibitory Control longitudinal study, which works with mother-child dyads. She is interested in pursuing a PhD in clinical psychology with a focus on neuroimaging in the future. 

Trainees

  • Emma Millon, PhD (She, Her)

    • Postdoctoral Research Fellow

    Dr. Emma Millon researches adaptive and maladaptive processes of self-regulation, with the goal of identifying brain and behavioral targets for treatment. She also investigates the impact of trauma on the development of psychiatric disorders in childhood and adolescence. Emma received her PhD from Rutgers in Behavioral Neuroscience where she studied the combined effects of meditation and aerobic exercise on brain health. She received her bachelor’s degree in English Literature from Harvard.

  • Katherine Dimitropoulou, PhD (She, Her)

    • Assistant Professor of Rehabilitation & Regenerative Medicine
  • Tracey Reznik, BA (She, Her)

    • MD-PhD Student

    Tracey is an MD-PhD student at Columbia University currently pursuing her doctoral research with Dr. Marsh and Dr. H. Blair Simpson. She received a BA in Economics from Harvard University. Her current research focuses on the use of machine learning methods and resting state fMRI in the diagnosis and classification of psychiatric disorders such as OCD.

Volunteers

  • Ariella Rosen (She, Her)

    • Volunteer Research Assistant
  • Gabby Brown, MA (She, Her)

    • Volunteer Research Assistant

    Gabrielle obtained her MA in Communications with an emphasis on education from the American University of Paris in 2019 while working at the United Nations Educational Scientific and Cultural Organization (UNESCO). Upon moving back to the United States, she began working at the University of California Irvine’s Neurocognitive Imaging Lab where she oversaw preprocessing of MRI DTI and PET-Resting PET-CPT scans. Currently she is a graduate student at Teachers College Columbia University seeking an MA in Developmental Psychology. Her research interests include cognitive development of infants and children, neurodevelopmental and neurocognitive disorders, and neuroimaging. She plans on pursing a PhD in Psychology.

  • Skyye James, BS (She, Her)

    • Volunteer Research Assistant

    Skyye James graduated from New York University in 2017 with a BS in Communicative Sciences and Disorders. After undergrad, she worked as a teacher for children with autism spectrum disorder (ASD) using the principles of applied behavior analysis (ABA) for 4 years. Skyye is currently working as a volunteer for the COMBO study as well as the Inhibitory control study. Her long-term goal is to become a Nurse Practitioner with a focus on child development. Skyye enjoys going to the Brooklyn botanical gardens and biking! 

  • Talia Rosen (She, Her)

    • Volunteer Research Assistant

    Talia Rosen is an undergraduate psychology student in the Barnard College Class of 2022. Her role as a volunteer with Dr. Marsh’s lab includes screening potential participants, organizing data, and recruiting new participants. She is planning to pursue a doctorate in clinical psychology after graduation and is interested in studying the treatment of various mental illnesses, including OCD and PTSD.

Select Publications

  • Cyr, M, Pagliaccio, D, Yanes-Lukin, P, Fontaine, M, Rynn, MA, & Marsh, R. (2020.) Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive–compulsive disorder. Neuropsychopharmacology. doi:10.1038/s41386-020-0613-3.

  • Pagliaccio, D, Cha, J, He, X, Cyr, M, Yanes‐Lukin, P, Goldberg, P, Fontaine, M, Rynn, MA & Marsh, R. (2020.) Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive‐compulsive disorder. J Child Psychol Psychiatr. doi:10.1111/jcpp.13191.

  • Pagliaccio D, Middleton R, Hezel D, Steinman S, Snorrason I, Gershkovich M, Campeas R, Pinto A, Van Meter P, Simpson HB, Marsh R.  (2019.) Task-based fMRI predicts response to exposure therapy in obsessive-compulsive disorder. Proceedings of the National Academy of Sciences; 116(41), 20346-20353. doi:10.1073/pnas.1909199116.

  • Berner L, Wang Z, Huo Z, Stefan M, Marsh R. (2019). Subcortical shape abnormalities in adolescents and adults with bulimia nervosa. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4(12), 1070-1079. doi:10.1016/j.bpsc.2018.12.011.

  • Margolis A, Davis K, Thomas L, Cyr M, Pao L, Marsh R. (2019). Neural correlates of cognitive control deficits in children with reading disorder. Brain Imaging and Behavior. doi:10.1007/s11682-019-00083-x.

  • Cyr M, Tau GZ, Fontaine M, Levin FR, Marsh R. (2018). Deficient functioning of fronto-striatal circuits during the resolution of cognitive conflict in cannabis-using youth. Journal of the American Academy of Child & Adolescent Psychiatry. 58(7), 702-711. doi:10.1016/j.jaac.2018.09.436.

  • Cyr M, Kopala-Sibley DC, Lee S, Chen C, Stefan M, Fontaine M, Terranova K, Berner LA, Marsh R. (2017.) Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up, Journal of the American Academy of Child & Adolescent Psychiatry. 56 (10): 866-874.  View PDF

  • Cyr M, Wang Z, Tau GZ, Zhao G, Friedl E, Stefan M, Terranova K, Marsh R. (2016.) Reward-Based Spatial Learning in Teens With Bulimia Nervosa, Journal of the American Academy of Child & Adolescent Psychiatry. 55 (11): 962-971. View PDF

  • Marsh R, Tau GZ, Wang Z, Huo Y, Liu G, Packard MJ, Peterson BS, Simpson HB. (2015.) Reward-based spatial learning in unmedicated adults with Obsessive-Compulsive Disorder, American Journal of Psychiatry, 172 (4): 383-92. View PDF

  • Marsh R, Stefan, M, Bansal R, Hao X, Walsh BT, Peterson BS. (2015.) Anatomical characteristics of the cerebral surface in bulimia nervosa, Biological Psychiatry. 77 (7): 616-23. View PDF

  • Marsh R, Horga G, Parashar N, Wang Z, Peterson BS, Simpson HB. (2013.) Altered activation in fronto-striatal circuits during sequential processing in unmedicated adults with obsessive-compulsive disorder. Biological Psychiatry. pii: S0006-3223(13)00147-9. View PDF

  • Marsh R, Horga G, Wang Z, Klahr K, Berner L, Walsh BT, Peterson BS. (2011.) An FMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa. American Journal of Psychiatry. 168 (11) 1210-20. View PDF

  • Marsh R, Maia T, Peterson BS. (2009.) Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies. American Journal of Psychiatry. 166/6: 664-74. View PDF

  • Marsh R, Gerber AJ, Peterson BS. (2008.) Neuroimaging Studies of Normal Brain Development & Their Relevance for Understanding Childhood Neuropsychiatric Disorders. Journal of the American Academy of Child and Adolescent Psychiatry. 47/11: 1233-51. View PDF