Selected Publications

Selected publications in reverse chronological order. Read a full list of publications here.

The ENIGMA-OCD Working Group (of which Dr. Helen Blair Simpson is a member): Mapping cortical and subcortical asymmetry in obsessive-compulsive disorder: Findings from the ENIGMA consortium. Biological Psychiatry 2020 (in press) Full text here.

Simpson HB, van den Heuvel OA, Miguel EC, Reddy YC, Stein DJ, Lewis-Fernández R, Shavitt RG, Lochner C, Pouwels PJW, Narayanawamy JC, Venkatasubramanian G, Hezel DM et al. Toward identifying reproducible brain signatures of obsessive-compulsive profiles. BMC Psychiatry 2020; 20(68) Full text here.

The ENIGMA-OCD Working Group (of which Dr. Helen Blair Simpson is a member): Intra-individual brain structural covariance networks in obsessive-compulsive disorder: A graph analysis from the ENIGMA Consortium. Brain 2020; 143(2): 684-700 Full text here.

Kayser RR, Raskin M, Snorrason I, Hezel DM, Haney M, Simpson HB: Cannabinoid augmentation of exposure-based psychotherapy for obsessive-compulsive disorder. Journal of Clinical Psychopharmacology 2020; 40(2):207-210 PMID: 32068563

Kayser RR, Snorrason I, Haney M, Lee FS, Simpson HB: The endocannabinoid system: a new treatment target for obsessive-compulsive disorder? Cannabis and Cannabinoid Research 2019; 4(2):1-11 Full text here.

Foa EB, Simpson HB, Rosenfield D, Liebowitz MR, Cahill S, Huppert JD, Bender J, McLean CP, Maher MJ, Campeas R, Hahn C, Imms P, Pinto A, Powers MB, Rodriguez CI, Van Meeter PE, Vermes D, Williams MT: Six-month outcomes from a randomized trial augmenting serotonin reuptake inhibitors with exposure and ritual prevention or risperidone in adults with obsessive-compulsive disorder. The Journal of Clinical Psychiatry 2015; 76(4): 440-446  PMID: 25375780  PMCID: PMC4524354 Full text here.

Marsh R, Horga G, Parashar N, Wang Z, Peterson BS, Simpson HB: Altered activation in fronto-striatal circuits during the sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder. Biological Psychiatry 2014; 75(8): 615-622  PMID: 23489416    PMCID: PMC3722261​ Full text here.

Posner J, Marsh R, Maia TV, Peterson BS, Gruber A, Simpson HB: Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder. Human Brain Mapping 2014; 35(6): 2852-2860  PMID: 24123377  PMCID: PMC4142493 Full text here.

Rodriguez CI, Kegeles LS, Levinson A, Feng T, Marcus SM, Vermes D, Flood P, Simpson HB: Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: Proof-of-concept. Neuropsychopharmacology 2013; 38(12): 2475-2483   PMID: 23783065  PMCID: PMC3799067 [This won the Neator Award for best paper in Neuropsychopharmacology in 2013.] Full text here.

​Simpson HB, Foa EB, Liebowitz MR, Huppert JD, Cahill S, Maher MJ, McLean CP, Bender J, Marcus SM, Williams MT, Waver J, Vermes D, van Meter PE, Rodriguez CI, Powers M, Pinto A, Imms P, Hahn C, Campeas R: Cognitive-behavioral therapy vs risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: A randomized clinical trial. JAMA Psychiatry 2013; 70(11): 1190-1199  PMID: 24026523  PMCID: PMC3955365 Full text here.

Foa EB, Simpson HB, Liebowitz MR, Powers MB, Rosenfield D, Cahill S, Campeas R, Franklin M, Hahn C, Hembree EA, Huppert JD, Schmidt AB, Vermes D, Williams MT: Six-month follow-up of a randomized controlled trial augmenting serotonin reuptake inhibitor treatment with exposure and ritual prevention for obsessive-compulsive disorder. The Journal of Clinical Psychiatry 2013; 74(5): 464-469    PMID: 23759449  PMCID: PMC3977336 Full text here.

Rodriquez CI, Bender J, Rynn M, Snape M, Simpson HB: Minocycline augmentation of pharmacotherapy in OCD: An open-label trial. The Journal of Clinical Psychiatry 2010; 71(9): 1247-1249  PMID: 20923629  PMCID: PMC3923525 Full text here.

Maher M, Huppert JD, Chen H, Duan N, Foa EB, Liebowitz MR, Simpson HB: Moderators and predictors of response to cognitive-behavioral therapy augmentation of pharmacotherapy in obsessive-compulsive disorder. Psychological Medicine 2010; 40(12): 2013-2023  PMID: 20416137  PMCID: PMC3953340 Full text here.

Simpson HB, Foa EB, Liebowitz MR, Ledley DR, Huppert JD, Cahill S, Vermes D, Schmidt AB, Hembree E, Franklin M, Campeas R, Hahn C-G, Petkova E: A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder. American Journal of Psychiatry 2008; 165(5): 621-630  PMID: 18316422  PMCID: PMC3945728 Full text here.

Foa EB, Liebowitz MR, Kozak MJ, Davies S, Campeas R, Franklin ME, Huppert JD, Kjernisted K, Rowan V, Schmidt AB, Simpson HB, Tu X: Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. American Journal of Psychiatry 2005; 162(1): 151-161  PMID: 15625214 Full text here.