Michael F. Grunebaum, MD

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Michael F. Grunebaum, M.D. is Associate Professor of Psychiatry at Columbia University Medical Center, and is a research psychiatrist at the New York State Psychiatric Institute. His areas of expertise include the diagnosis and treatment of mood disorders, with a focus on suicidal behavior and clinical trial research.

Dr. Grunebaum graduated magna cum laude and phi beta kappa from Harvard College in 1983 and received his M.D. from Harvard Medical School in 1991. He completed his residency in psychiatry at the Payne Whitney Psychiatric Clinic, New York Hospital-Cornell Medical Center, in 1995. He completed the Public Psychiatry Fellowship at Columbia University-New York State Psychiatric Institute and received his board certification in psychiatry in 1996.

Dr. Grunebaum is a recipient of NARSAD Young Investigator and Independent Investigator awards,an NIMH patient-oriented research career development K Award, and an NIMH R01 grant to conduct treatment studies in adults with mood disorders and a history of suicidality. He is a research psychiatrist on other federally funded clinical studies of mood disorders and suicidal behavior in the Molecular Imaging and Neuropathology Division.

Dr. Grunebaum teaches psychiatry residents and other trainees. He is a peer reviewer for numerous psychiatric journals and a member of the American Psychiatric Association. He is an author of more than 50 peer reviewed articles and other publications.

Dr. Grunebaum also has a general adult private practice of psychotherapy and psychopharmacology.

Areas of Expertise / Conditions Treated

  • Anxiety
  • Anxiety Disorders
  • Mood and Anxiety Disorders
  • Mood Disorder
  • Mood Disorders

Academic Appointments

  • Associate Professor of Psychiatry at CUMC

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Male

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Credentials & Experience

Education & Training

  • Harvard Medical School
  • Residency: NewYork-Presbyterian Hospital/Weill Cornell Medical Center

Board Certifications

  • Psychiatry

Honors & Awards

2008 NCDEU New Investigator Award

2008 Fellowship to attend ASCP Workshop on Clinical Trials in Psychopharmacology

1994 The New York Psychoanalytic Institute Fellowship Program for Psychiatry Residents

1988 Andrew Sellard Fellowship, Harvard Medical School, for public health research in Santiago, Chile

1983 Phi Beta Kappa, Harvard College, Cambridge, MA


Clinical research on treatments for depression and suicidality: NIMH R01 clinical trial of ketamine for depression with suicidal thoughts

Research Interests

  • Bipolar Disorder
  • Depression (Major Depressive Disorder)

Selected Publications

  • Grunebaum MF, Ellis SP, Duan N, Burke AK, Oquendo MA, Mann JJ.: Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression.. Neuropsychopharmacology 2012;37: 697-706
  • Grunebaum MF, Ellis SP, Li S, Oquendo MA, Mann JJ: Antidepressants and suicide risk in the United States, 1985-1999.. J Clin Psychiatry 2004 Nov;65(11): 1456-62
  • Grunebaum MF, Galfalvy HC, Oquendo MA, Burke AK, Mann JJ: Melancholia and the probability and lethality of suicide attempts.. Br J Psychiatry Jun 2004;184: 534-5
  • Grunebaum MF, Galfalvy HC, Huang YY, Cooper TB, Burke AK, Agnello M, Oquendo MA, Mann JJ. : Association of X-box binding protein 1 ( XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episode. Int J Neuropsychopharmacology 2009;75(3): 281-3
  • Grunebaum MF, Galfalvy HC, Mortenson LY, Burke AK, Oquendo MA, Mann JJ: Attachment and social adjustment: Relationships to suicide attempt and major depressive episode in a prospective study. J Affect Disord. 2009 Oct 8 2009;8: 123-30