Melanie Wall, PhD

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Overview

Academic Appointments

  • Professor of Biostatistics (in Psychiatry)

Dr. Wall has worked extensively with modeling complex multilevel and multimodal data on a wide array of psychosocial public health and psychiatric research questions in both clinical studies and large epidemiologic studies. She is an expert in longitudinal data analysis and latent variable modeling, including structural equation modeling focused on mediating and moderating (interaction) effects where she has made many methodological contributions. She has a long track record as a biostatistical mentor for Ph.D. students and NIH K awardees and regularly teaches graduate level courses in the Department of Biostatistics in the Mailman School of Public Health attended by clinical Masters students, Ph.D. students, post-docs, and psychiatry fellows. Her current research mission is improving the accessibility and application of state-of-the-art and reproducible statistical methods across different areas psychiatric research. 

Research

My current research mission is improving the accessibility and application of state-of-the-art and reproducible statistical methods across different areas psychiatric research.  For example, I am currently the Quantitative Unit Methods Core director of the OPAL NIMH funded center grant aimed at improving care for people with schizophrenia. The quantitative methods core aims to use flexible and data-adaptive statistical and machine learning methods to determine who will benefit most from each intervention by identifying (possibly high-dimensional) tailoring variables as well as develop statistical methods suitable for building optimal multistage treatment regimens for patients with schizophrenia.  Another example is my leadership in the statistical analyses of national data monitoring the impact of drug policy change (i.e. medical and recreational marijuana laws, opioid prescribing practices, Affordable Care Act) on substance use disorder rates, mortality, and treatment. 

Research Interests

  • Biostatistics

Grants

EATING, ACTIVITY, AND WEIGHT-RELATED PROBLEMS ACROSS THE LIFE COURSE IN DIVERSE POPULATIONS (Federal Gov)

Jan 16 2018 - Nov 30 2024

PRENATAL EXPOSURE TO ANESTHESIA AND SUBSEQUENT NEURODEVELOPMENTAL DISORDERS (Federal Gov)

Sep 30 2018 - Jul 31 2023

CENTER FOR RESEARCH ON ETHICAL, LEGAL & SOCIAL IMPLICATIONS OF PSYCHIATRIC, NEUROLOGIC & BEHAVIORAL GENETICS (Federal Gov)

Sep 17 2018 - Jun 30 2022

THE NEUROBIOLOGY OF VIOLENCE IN A PSYCHOSIS-RISK COHORT (Federal Gov)

Sep 1 2017 - May 31 2022

IMPROVING COGNITION VIA EXERCISE IN SCHIZOPHRENIA (Federal Gov)

Sep 15 2017 - Jul 31 2021

STATE MEDICAL MARIJUANA LAWS AND NSDUH MARIJUANA USE AND CONSEQUENCES SINCE 2004 (Federal Gov)

Sep 15 2014 - Aug 31 2020

RISK AND BENEFITS OF OVERDOSE EDUCATION AND NALOXONE PRESCRIBING TO HEROIN USERS (Federal Gov)

Sep 15 2014 - Aug 31 2020

GLUTAMATE REDUCING INTERVENTIONS IN SCHIZOPHRENIA (Federal Gov)

Jul 5 2017 - Jun 30 2020

PREDICTORS OF HIGH-RISK BEHAVIOR AMONG YOUTH (MARTINS/BLANCO/CANINO/DUARTE) (Federal Gov)

Mar 1 2009 - Mar 31 2020

HEALTHCALL: ENHANCING BRIEF INTERVENTION FOR HIV PRIMARY CARE ALCOHOL DEPENDENCE (Federal Gov)

Sep 25 2014 - Jul 31 2019

ONTRACKCHILE FOR FIRST EPISODE PSYCHOSIS (Federal Gov)

Aug 7 2018 - Jun 30 2019

PRESCRIPTION DRUG USE IN THE US POPULATION:GATEWAY EFFECTS AND FAMILY PATTERNS (Federal Gov)

Apr 1 2015 - Jun 30 2019

DSM-IV AND DSM-5 ALCOHOL/SUBSTANCE DISORDERS: RELIABILITY, VALIDITY IN NESARC-III (Federal Gov)

Jul 1 2014 - Jun 30 2019

DEFICIENT BELIEF UPDATING AS A CONVERGENT COMPUTATIONAL MECHANISM OF PSYCHOSIS (Federal Gov)

Sep 1 2018 - May 31 2019

RISK AND BENEFITS OF OVERDOSE EDUCATION AND NALOXONE PRESCRIBING TO HEROIN USERS (Federal Gov)

Sep 15 2014 - Aug 31 2018

ROLE OF DEPRESSION AND ANXIETY IN THE TOBACCO EPIDEMIC (Federal Gov)

Jul 3 2017 - Jun 30 2018

COMPARATIVE EFFECTIVENESS OF ADAPTIVE PHARMACOTHERAPY STRATEGIES FOR SCHIZOPHRENIA (Private)

Jul 1 2015 - Jun 30 2018

BIOMARKERS OF CONVERSION RISK AND TREATMENT RESPONSE IN EARLY-STAGE SCHIZOPHRENIA (Federal Gov)

Sep 15 2017 - May 31 2018

PHYSICAL AND MENTAL FATIGABILITY IN LATE LIFE CLINICAL POPULATIONS (Federal Gov)

Sep 1 2016 - Apr 30 2018

RISK AND BENEFITS OF OVERDOSE EDUCATION AND NALOXONE PRESCRIBING TO HEROIN USERS (Federal Gov)

Sep 15 2014 - Feb 28 2018

RISK AND BENEFITS OF OVERDOSE EDUCATION AND NALOXONE PRESCRIBING TO HEROIN USERS (Federal Gov)

Sep 15 2014 - Aug 31 2017

MECHANISMS OF ANTIDEPRESSANT NONRESPONSE IN LATE LIFE DEPRESSION (Federal Gov)

Jan 1 2015 - Dec 31 2016

RISK AND BENEFITS OF OVERDOSE EDUCATION AND NALOXONE PRESCRIBING TO HEROIN USERS (Federal Gov)

Sep 15 2014 - Aug 31 2016

IMPACT OF THE GROWING MENTAL HEALTH DISPARITY IN SMOKING ON THE ENDURING TOBACCO EPIDEMIC (Federal Gov)

Sep 15 2014 - Jun 30 2016

PROJECT EAT-IV: EATING AND ACTIVITY IN ADOLESCENTS AND YOUNG ADULTS (Federal Gov)

Aug 12 2013 - Jun 30 2016

INFLUENCES OF PARENTAL SMOKING ON ADOLESCENT SMOKING IN THE US POPULATION (Private)

Sep 1 2013 - Aug 31 2015

MECHANISMS OF ANTIDEPRESSANT NON-RESPONSE IN LATE-LIFE DEPRESSION (Federal Gov)

Jan 1 2014 - Dec 31 2014

COMPARATIVE EFFECTIVENESS OF DEVELOPMENT-BHAVIORAL SCREENING INSTRUMENTS (Federal Gov)

Jan 10 2013 - Dec 31 2014

MULTILEVEL LATENT CLASS AND SOCIAL NETWORK MODELS FOR OBSERVATIONAL AND ADOLESCENT OBESITY DATA (Federal Gov)

Aug 10 2009 - Jul 31 2014

SURVIVING VIETNAM: THE PSYCHOLOGICAL CONSEQUENCES OF THE WAR FOR U.S. VETERANS (Private)

Dec 15 2012 - Jun 1 2014

PROJECT EAT-III: EATING AMONG TEENS AND YOUNG ADULTS (Federal Gov)

Jul 1 2010 - May 31 2013

PROJECT EAT-III: EATING AMONG TEENS AND YOUNG ADULTS (Federal Gov)

Jul 1 2010 - May 31 2012

Selected Publications

  • Sarvet A, Wall M, Fink D, Greene E, Le A, Boustead A, Pacula R, Keyes K, Cerda M, Galea S, Hasin D.  Medical marijuana laws and adolescent marijuana use in the United States: a systematic review and meta-analysis.  Addiction. 113(6): 1003-1016. 2018.
  • Wall MM, Hu M, Griesler P, Cheslack-Postave K, Feng T, Kandel D. Nonmedical Prescription Opioids and Pathways of Drug Involvement in the US: Generational Differences.  Drug and Alcohol Dependence, 182, 103-111. 2018.
  • Nossel I, Wall MM, Scodes J, Marino L, Zikha S, Bello I, Malinovsky I, Lee R, Radigan M, Smith T, Sederer L, Gu G, Dixon L. Results of a coordinated specialty care program for early psychosis and predictors of outcomes. Epub ahead of print in Psychiatric Services, 2018.
  • Olfson M, Wall M, Liu S, Wang S, Crystal S, Blanco C.  Risks of fatal opioid overdose during the first year following nonfatal overdose.  Epub ahead of print in Drug and Alcohol Dependence. 2018.
  • Raffo C, Hasin D, Appelbaum P, Wall M.  A data-driven method for identifying shorter symptom criteria sets: The case for DSM-5 alcohol use disorder. Epub ahead of print in Psychological Medicine, 2018