Xi Zhu, PhD

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Dr. Zhu is an Assistant Professor of Clinical Neurobiology (in Psychiatry) at Columbia University, College of Physicians and Surgeons, and research scientist at the New York State Psychiatric Institute. Dr. Zhu's research is committed to uncover complex relationships among neural biomarkers, clinical symptoms and health outcomes to advance diagnostics and treatment selection of mental disorders. My methodological interests include machine learning/deep learning, network analysis, longitudinal data analysis, and latent factor analytics for precision medicine. This work is funded by grants from the National Institute of Mental Health, and Brain and Behavior Research Foundation.

Academic Appointments

  • Assistant Professor of Clinical Neurobiology (in Psychiatry)


  • English
  • Mandarin


  • Female


Research Interests

  • Alcohol Use Disorder
  • Post-traumatic Stress Disorder (PTSD)

Selected Publications

X. Zhu, B. Suarez-Jimenez, S. Zilcha-Mano, etc. (2021):  Neural Changes Following Equine-Assisted Therapy for PTSD: A Longitudinal Multimodal Imaging Study. Human Brain Mapping.    


S. Zilcha-Mano*, X. Zhu*, A. Lazarov, B. Suarez-Jimenez, et al., (2020):  Diagnostic and Predictive Neuroimaging Biomarkers for Posttraumatic Stress Disorder: A Machine Learning Study. Biological Psychiatry: CNNI.     


B. Suarez-Jimenez, X. Zhu*, A. Lazarov, J. J. Mann, F. Schneier, A. Gerber, J. P. Barber, D. L. Chambless, Y. Neria, B. Milrod and J. C. Markowitz (2019). “Anterior hippocampal volume predicts affect-focused psychotherapy outcome.” Psychol Med: 1-7. PMID: 30773148    


X. Zhu, B. Suarez-Jimenez, A. Lazarov, L. Helpman, S. Papini, A. Lowell, A. Durosky, M. A. Lindquist, J. C. Markowitz, F. Schneier, T. D. Wager and Y. Neria (2018). "Exposure-based therapy changes amygdala and hippocampus resting-state functional connectivity in patients with posttraumatic stress disorder." Depression Anxiety: 35(10): 974-984. PMC6168398    


X. Zhu, X. Du, M. Kerich, F. W. Lohoff and R. Momenan (2018). "Random forest-based classification of alcohol dependence patients and healthy controls using resting state MRI." Neuroscience Letter 676: 27-33. PMC5960433    


M. A. Fullana, X. Zhu*, P. Alonso, N. Cardoner, E. Real, C. Lopez-Sola, C. Segalas, M. Subira, H. Galfalvy, J. M. Menchon, H. B. Simpson, R. Marsh and C. Soriano-Mas (2017). "Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder." J Psychiatry Neurosci 42(6): 378-385. PMC5662459    


X. Zhu, C. R. Cortes, K. Mathur, D. Tomasi and R. Momenan (2017). "Model-free functional connectivity and impulsivity correlates of alcohol dependence: a resting-state study." Addiction Biology 22(1): 206-217. PMC4669235    


X. Zhu, L. Helpman, S. Papini, F. Schneier, J. C. Markowitz, P. E. Van Meter, M. A. Lindquist, T. D. Wager and Y. Neria (2017). "Altered resting state functional connectivity of fear and reward circuitry in comorbid PTSD and major depression." Depression Anxiety 34 (7): 641-650. PMC5667358