Steven Ellis, PhD

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Overview

Academic Appointments

  • Associate Professor of Clinical Neurobiology in Psychiatry

Steven P. Ellis, Ph.D. is Associate Prof. of Clinical Neurobiology (in Psychiatry). He is Director, Statistics and Computing Core, Conte Center: Neurobiological and Developmental Antecedents to Suicidal Behavior: The Neurobiology of Suicidal Behavior (CCNDASB). He is also PI on Project 8 of the CCNDASB, "Statistical methods in suicide research." He graduated cum laude, with Honors with Exceptional Distinction in Mathematics, and with a masters degree in mathematics awarded simultaneously with the bachelor's degree after four years at Yale. He also was awarded the DeForest Mathematical Prize at Yale. He was awarded an NSF Graduate Fellowship in mathematics.

Dr. Ellis was PI on the grant "Statistical Analysis of Neurochemical Maps" (R21 MH60995, NIMH). Dr. Ellis's interests include multivariate analysis and statistical computing.

Research

Dr. Ellis is interested in statistical prediction of suicide attempts, statistical computing, and instability of multivariate statistical methods.

Currently, Dr. Ellis is developing new statistical measures of high-order statistical dependence. When there are many variables this is a very challenging problems. However, a method called "concurrence topology" developed by Ellis is often successful in detecting interesting forms of high-order dependence. A paper by Arno Klein and Ellis applying this method to resting state fMRI data has recently been accepted for publication.

In a different direction, Ellis has discovered that for many multivariate statistical methods there are many data sets at which the method fails catastrophically. This had already been known to a limited extent, i.e., failure due to outliers or, in particular cases, due to ill conditioning of certain matrices. But Ellis has shown the extent of this problem is far greater than previously suspected. He is investigating the breadth and depth of the problem.

Grants

TOPOLOGY OF CANCER EVOLUTION AND HETEROGENEITY (Federal Gov)

May 19 2015 - Apr 30 2020

POSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDE (Federal Gov)

Aug 8 2013 - Jun 30 2018

POSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDE (Federal Gov)

Aug 8 2013 - Jun 30 2017

KETAMINE VS MIDAZOLAM: TESTING RAPID RELIEF OF SUICIDE RISK IN DEPRESSION (Federal Gov)

Oct 1 2015 - Apr 30 2017

KETAMINE VS MIDAZOLAM: TESTING RAPID RELIEF OF SUICIDE RISK IN DEPRESSION (Federal Gov)

Jul 5 2012 - Apr 30 2017

5-HT1A RECEPTOR ANTI-APOPTOTIC TRANSDUCTION PATHWAYS IN SUICIDE (Federal Gov)

Mar 1 2008 - Aug 31 2015

Selected Publications

  • Ellis SP: Fitting a line to three or four points on a plane. SIAM Review 2002;44: 616-628
  • Ellis, S.P. and Klein, A.: Describing high-order statistical dependence using ``concurrence topology'', with application to functional MRI brain data. Homology, Homotopy, and Applications 2014;16: 245--264
  • Ellis SP: Instability of statistical factor analysis. Proceedings of the American Mathematical Society 2004;132: 1805-1822
  • Ellis SP: Some issues in suicide attempt prediction, ENAR (American Statistical Association), Alexandria, VA, 2008
  • Ellis SP, Stewart JW: Temporal dependence and bias in meta-analysis. Communications in Statistics - Theory and Methods (in press)