Patrick J. Brown, PhD

  • Associate Professor of Clinical Medical Psychology (in Psychiatry)
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Patrick J. Brown, PH.D. is an Associate Professor of Clinical Medical Psychology in Psychiatry at the College of Physicians & Surgeons, Columbia University, and a Research Scientist at the New York State Psychiatric Institute in the Neurobiology and Therapeutics of Aging Division (NTAD). He serves as the Director for the NIMH-funded T32 Research Fellowship in Late Life Neuropsychiatric Disorders, overseeing the training of research fellows interested in becoming independent scientists in the area of aging and psychiatric illness.


Dr. Brown’s research focuses on the intersection between aging processes and late life neuropsychiatric disorders. He was awarded a Junior Investigator Award by the National Alzheimer’s Coordinating Center for his research on functional impairment in cognitively impaired elders. His research has been funded by the National Institute of Aging and the National Institute of Mental Health focusing on the phenomenology and antidepressant treatment of frail, depressed older adults, the biological and clinical correlates of both cognitive and physical fatigability in older adults, and disentangling the relationship between changes in cognition and antidepressant medication treatment in older adults with treatment resistant depression.


Dr. Brown received his undergraduate degree from the College of the Holy Cross, and his doctoral degree from Washington University in St. Louis. He completed his pre-doctoral internship training at Montefiore Medical Center in the Bronx, NY, and a National Institute of Mental Health postdoctoral research fellowship in Late Life Neuropsychiatric Disorders at Columbia University. Dr. Brown is a NY State licensed clinical psychologist and practices empirically supported treatments, primarily cognitive behavioral therapy for the treatment of both depressive and anxiety disorders in adults.

Academic Appointments

  • Associate Professor of Clinical Medical Psychology (in Psychiatry)


  • Male


Research Interests

  • Affective Disorders
  • Cognitive Behavioral Therapy
  • Neuropsychiatric Disorders of Late Life

Selected Publications

  • Brown, P.J., Fieo, R., Roose, S.P., Liu, X., Sneed, J.R., Rutherford, B.R., Devanand, D.P., Avlund, K.: Frailty and depression in older adults: A high-risk clinical population. Amer J of Geri Psychiatry In Press
  • Brown, P.J., Rutherford, B.R., Roose, S.P.: The Difficult Choices We Must Make When Studying Complex Patients. Guest Editorial.. Amer J of Geri Psychiatry 2013;21: 1049-1051
  • Brown, P.J., Liu, X., Devanand, D.P., Sneed, J.R., Roose, S.P. : Speed of processing mediates the relationship between depression and impaired function in older adults with mild cognitive impairment.. Amer J of Geri Psychiatry 2013;21: 675-684
  • Brown, P.J., Devanand, D.P., Liu, X., Caccappolo, E., and the Alzheimer's Disease Neuroimaging Initiative: Characteristics and correlates of functional impairment in the elderly with mild cognitive impairment and mild Alzheimer's disease. . Archives of General Psychiatry 2011;68: 617-626
  • Brown, P.J., Woods, C., & Storandt, M. : Model stability of the 15-Item Geriatric Depression Scale across cognitive impairment and severe depression.. Psychology and Aging 2007;22: 372-379
  • Brown PJ, Devanand DP, Liu X, Caccappolo E. Functional impairment in elderly patients with mild cognitive impairment and mild Alzheimer disease. JAMA Psychiatry. 2011 Jun;68(6):617-26. doi: 10.1001/archgenpsychiatry.2011.57. 
  • Brown PJ, Roose SP, Zhang J, Wall M, Rutherford BR, Ayonayon HN, Butters MA, Harris T, Newman AB, Satterfield S, Simonsick EM, Yaffe K. Inflammation, Depression, and Slow Gait: A High Mortality Phenotype in Later Life. J Gerontol A Biol Sci Med Sci.2016 Feb;71(2):221-7. doi: 10.1093/gerona/glv156.
  • Brown PJ, Brennan N, Ciarleglio A, Chen C, Garcia CM, Gomez S, Roose SP, Rutherford BR, Simonsick EM, Spencer RG, Ferrucci L. Declining Skeletal Muscle Mitochondrial Function Associated With Increased Risk of Depression in Later Life. Am J Geriatr Psychiatry. 2019 Sep;27(9):963-971. doi: 10.1016/j.jagp.2019.03.022. 
  • Brown PJ, Ciarleglio A, Roose SP, et al. Frailty Worsens Antidepressant Treatment Outcomes in Late Life Depression. Am J Geriatr Psychiatry 2020 in press.