M. Elizabeth Sublette, MD, PhD

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Overview

Academic Appointments

  • Associate Professor of Clinical Psychiatry

M. Elizabeth Sublette received her MD/PhD from SUNY Downstate. She completed a psychiatry residency at the Zucker Hillside Hospital, North Shore - Long Island Jewish Medical Center and served as Chief of the Affective Disorders inpatient unit at Zucker Hillside Hospital before coming to Columbia University

After completing an NIH-funded T32 postdoctoral fellowship in the Division of Child and Adolescent Psychiatry, Dr. Sublette joined the faculty in 2007, as an Assistant Professor of Clinical Psychiatry and a Research Scientist at the New York State Psychiatric Institute, in the Division of Molecular Imaging and Neuropathology.

Dr. Sublette's research focuses on the neurobiology of mood disorders and suicide risk. In particular, she has concentrated on understanding the effects of omega-3 fatty acids on brain and mood. Her research has been funded by NARSAD, the American Foundation for Suicide Prevention (AFSP), and the National Institute of Mental Health (NIMH).

Research

Role of essential dietary fatty acids in the neurobiology of mood disorders and suicide risk

Dr. Sublette's previous studies have found links between low omega-3 fatty acids and risk of later suicide attempt; and between omega-3 blood levels and specific patterns of regional brain glucose uptake. Using positron emission tomography (PET scanning), biochemical analysis, and clinical assessment, the current research projects are expected to shed light on how human nutrition may directly affect the brain and ultimately influence mood.

Research Interests

  • I am interested in the role of essential dietary fatty acids in the neurobiology of mood disorders and suicide risk.
  • Mood Disorders

Grants

NEUROBIOLOGICAL UNDERPINNINGS OF TWO SUICIDAL SUBTYPES (Federal Gov)

May 15 2016 - Feb 28 2021

KETAMINE VS MIDAZOLAM: TESTING RAPID RELIEF OF SUICIDE RISK IN DEPRESSION (Federal Gov)

Jul 5 2012 - Apr 30 2017

NEUROBIOLOGY OF DEPRESSION AND ANTIDEPRESSANTS (Federal Gov)

Mar 1 1990 - Jan 31 2016

STRESS AND SUICIDE: IMPACT OF OMEGA-3 FATTY ACID DEFICIENCY ON INFLAMMATION AND SUDICIDAL BEHAVIOR (Private)

Oct 1 2013 - Sep 30 2015

KETAMINE VS MIDAZOLAM: TESTING RAPID RELIEF OF SUICIDE RISK IN BIPOLAR DISORDER (Private)

Sep 15 2013 - Sep 14 2015

FUTURE SUICIDE ATTEMPT: PSYCHOBIOLOGICAL FEATURES (Federal Gov)

May 1 1992 - Nov 30 2014

NEUROIMAGING OF FATTY ACIDS IN MAJOR DEPRESSION (Federal Gov)

Apr 1 2008 - Jan 31 2014

ASSESSING THE RELATIONSHIPS BETWEEN PLASMA FATTY ACID LEVELS AND BRAIN SEROTONERGIC FUNCTIONING IN MAJOR DEPRESSIVE DISO (Private)

Jul 1 2007 - Jun 30 2010

RESEARCH TRAINING IN CHILD PSYCHIATRY (Federal Gov)

Sep 25 1980 - Jun 30 2010

Selected Publications

  • Gopaldas M, Zanderigo F, Zhan S, Ogden RT, Miller JM, Rubin-Falcone H, Cooper TB, Oquendo MA, Sullivan G, Mann JJ, Sublette ME: Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression. Journal of Affective Disorders 2019;257:495–503. http://doi.org/10.1016/j.jad.2019.07.035 PMID: 31319341
  • Zanderigo F, Kang Y, Kumar D, Nikolopoulou A, Mozley PD, Kothari PJ, He B, Schlyer D, Rapoport SI, Oquendo MA, Vallabhajosula S, Mann JJ, Sublette ME: [11C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use. Synapse 2018;72(2). doi: 10.1002/syn.22018. PMCID: PMC6075823.
  • Cheung, S.G., Goldenthal, A.R., Uhlemann, A.-C., Mann, J.J., Miller, J.M., Sublette, M.E.: Systematic review of gut microbiota and major depression. Frontiers in Psychiatry: Mood and Anxiety Disorders (2019) 10(34):1-17. doi: 10.3389/fpsyt.2019.00034. eCollection 2019. PubMed Central PMCID: PMC6378305.
  • Sublette, M.E., Editorial: Grappling with suicide risk. Mayo Clinic Proceedings 2018;93(6):682-683. doi: 10.1016/j.mayocp.2018.04.006. Epub 2018 May 9. PubMed PMID: 29753497.
  • Daray, F.M., Mann, J.J., Sublette, M.E.: How lipids may affect risk for suicidal behavior. Journal of Pyschiatric Research 2018;104:16-23. doi: 10.1016/j.jpsychires.2018.06.007. PMCID: PMC6102068.