John J. Mariani, MD

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Overview

Academic Appointments

  • Associate Professor of Clinical Psychiatry

Administrative Titles

  • Director, Substance Treatment and Research Service

Dr. John Mariani is an Associate Professor of Clinical Psychiatry at the College of Physicians and Surgeons of Columbia University and a Research Psychiatrist at the New York State Psychiatric Institute. After receiving his medical degree from the New York University School of Medicine and completing his psychiatry residency at the Beth Israel Medical Center in New York City, where he served as Chief Resident, Dr. Mariani began a two-year addiction psychiatry research fellowship at Columbia University. In 2005, he joined the faculty of the Division on Substance Abuse as a Research Psychiatrist. Under the mentorship of Dr. Frances Levin, he has remained active in clinical research and is the recipient of a K-23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Drug Abuse. Currently, Dr. Mariani is the Director of Columbia University’s Substance Treatment and Research Service (STARS). His research has primarily focused on investigating novel pharmacotherapies for addictive disorders.

Gender

  • Male

Credentials & Experience

Education & Training

  • MD, Medicine, New York University School of Medicine
  • Internship: Mount Sinai Medical Center
  • Residency: Beth Israel Medical Center, NY
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Research

Development of novel pharmacotherapies for substance use disorders.

Dr. Mariani is the principal investigator (PI) of a NIDA-funded R01,"Quetiapine Pharmacotherapy for Cannabis Dependence". The goal of this double-blind study is to study the effects of quetiapine on cannabis dependence, the hypothesis being that the sedating, appetite stimulating and anxiolytic effects of quetiapine will reduce cannabis withdrawal symptoms. Dr. Mariani is also the principal investigator of NIAAA-funded R21 AA017691, "Gabapentin for Abstinence Initiation in Alcohol Dependence". The goal of this double-blind pilot project is to study the effects of gabapentin treatment of alcohol dependence in an abstinence-initiation model, where participants are actively using alcohol at study entry, and the change in use pattern from baseline is measured throughout the study period.

Research Interests

  • Psychiatry

Clinical Trials

Current clinical trials:

  • Gabapentin for Abstinence Initiation in Alcohol Dependence (GAINS).  Learn more.
  • Quetiapine Pharmacotherapy for Cannabis Dependence.  Learn more.

Grants

QUETIAPINE TREATMENT FOR CANNABIS DEPENDENCE (Federal Gov)

Aug 1 2012 - Aug 31 2016

1/2 MULTICENTER TRIAL OF COMBINED PHARMACOTHERAPY TO TREAT COCAINE DEPENDENCE (Federal Gov)

Apr 1 2013 - Feb 29 2016

IMPROVED STRATEGIES FOR OUTPATIENT OPIOID DETOXIFICATION (Federal Gov)

Jun 1 2011 - Apr 30 2015

NEPICASTAT/COCAINE TRIAL (Federal Gov)

Dec 1 2012 - Mar 31 2015

MULTI-SITE CONTROLLED TRIAL OF COCAINE VACCINE (6 OF 6) COLUMBIA UNIVERSITY SITE (Federal Gov)

Sep 15 2008 - Jul 31 2013

ANTICONVULSANT PHARMACOTHERAPY FOR SEDATIVE-HYPNOTIC USE DIS ORDERS (Federal Gov)

May 1 2006 - Apr 30 2012

Selected Publications

  • Mariani JJ, Brooks D, Haney M, Levin FR. : Quantification and comparison of marijuana smoking practices: Blunts, joints, and pipes..  Drug and Alcohol Dependence  2010;DOI:10.1016/j.drugalcdep.2010.08.008 
  • Mariani JJ. Horey J. Bisaga A. Aharonovich E. Raby W. Cheng WY. Nunes E. Levin FR.: Antisocial behavioral syndromes in cocaine and cannabis dependence..  American Journal of Drug & Alcohol Abuse  2008;34(4): 405-414 
  • Mariani JJ, Levin FR: Treatment Strategies for Co-Occurring ADHD and Substance Use Disorders.  American Journal on Addictions   2006;16(supp. 1): 45-56 
  • Mariani JJ, Rosenthal RN, Tross S, Singh P, Anand O: A Randomized Open-Label Controlled Trial of Gabapentin and Phenobarbital in the Treatment of Alcohol Withdrawal.  American Journal on Addictions  2006;15(1): 76-84 
  • Mariani JJ: Alcohol-Related Disorders. In Gabbard's Treatments of Psychiatric Disorders, Glen O. Gabbard, editor in chief.—4th edition.,  APA Psychiatric Publishing, Inc.,  Arlington,  VI,  US