Guillermo Horga, MD, PhD
- Assistant Professor of Clinical Psychiatry
Credentials & Experience
Education & Training
- MD, 2004 Medicine and Surgery Degree, Miguel Hernández University
- PhD, 2015 Clinical and Experimental Neurosciences, University of Barcelona (Spain)
- Residency: 2009 Hospital Clinic of Barcelona
- Fellowship: 2012 Columbia University (NY)
My lab mainly focuses on the neurobiological and computational mechanisms of psychotic symptoms in schizophrenia and of related cognitive functions in health, including sensory and reward-based learning and decision-making. Psychosis is characterized by the experience of abnormal percepts, such as hallucinations, and delusional beliefs. While excessive dopamine transmission in the striatum is known to play a role in these symptoms, the cognitive and computational mechanisms mediating psychotic experiences remain unclear.
To understand these neural mechanisms, our research uses behavioral paradigms and computational tools in combination with a variety of functional, structural and molecular in vivo neuroimaging techniques (mainly functional Magnetic Resonance Imaging [fMRI] and Positron Emission Tomography [PET]) in healthy humans and patients with psychotic disorders. We also use pharmacological manipulations to understand the relationships between neurotransmission and specific neural computations, and collaborate with other groups to collect invasive and non-invasive electrophysiological data relevant to our research focus.
Our prior research showed that voice-sensitive regions of the auditory cortex have increased activity while patients experience auditory hallucinations of voices (Horga et al., J Neurosci 2014; Horga et al., J Psychiatry Neurosci 2011). This hallucination-related increase in neural activity was further associated with abnormal learning signals, suggesting that a learning dysfunction could lead to faulty sensory attenuation and hallucinatory percepts (Horga et al., J Neurosci 2014). We have also discovered that abnormal functional connectivity between the striatum and associative cortical regions, including parts of the auditory cortex, relate to psychosis and dopamine receptor density (Horga et al., JAMA Psychiatry 2016). Our current projects aim at elucidating the relationships between dopamine abnormalities and downstream cortical dysfunctions associated with specific symptoms of psychosis and to formalize these mechanisms in a computational model of psychosis.
- Cognitive/Systems Neuroscience
- Brain Imaging
- Neurobiology of Learning and Memory
INDIVIDUALIZED RISK PREDICTION IN PERSONS AT CLINICAL HIGH RISK FOR PSYCHOSIS USING NERUOMELANIN-SENSITIVE MRI (Federal Gov)
Sep 1 2018 - May 31 2023
BRAIN AND BEHAVIORAL INDICATORS OF RISK FOR PARKINSONISM AMONG ADOLESCENTS WITH EARLY PESTICIDE EXPOSURE (Federal Gov)
Jan 15 2019 - Dec 31 2022
DEFICIENT BELIEF UPDATING AS A CONVERGENT COMPUTATIONAL MECHANISM OF PSYCHOSIS (Federal Gov)
Sep 1 2018 - May 31 2019
SENSORY-LEARNING DEFICITS AND CONVERSION TO PSYCHOSIS AMONG INDIVIDUALS AT CLINICAL HIGH-RISK: A LONGITUDINAL MODEL-BASED FMRI STUDY (Federal Gov)
Jul 1 2017 - Jun 30 2018
INVESTIGATING THE PHYSIOLOGY OF HUMAN DECISION-MAKING (Private)
Nov 1 2013 - Oct 31 2016
CLINICAL AND TRANSLATIONAL SCIENCE AWARD (Federal Gov)
Sep 30 2006 - Jun 30 2016
A LONGITUDINAL MULTIMODAL MRI STUDY OF ADOLESCENTS WITH BULIMIA NERVOSA (Federal Gov)
Jan 1 2012 - May 31 2016
Horga G, Cassidy CM, Xu X, Moore H, Slifstein M, Van Snellenberg JX, Abi-Dargham A. Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia. JAMA Psychiatry. 2016 May 4.
Cassidy CM, Van Snellenberg JX, Benavides C, Slifstein M, Wang Z, Moore H, Abi-Dargham A, Horga G. Dynamic Connectivity between Brain Networks Supports Working Memory: Relationships to Dopamine Release and Schizophrenia. J Neurosci. 2016 Apr 13;36(15):4377-88.
Horga G, Schatz KC, Abi-Dargham A, Peterson BS. Deficits in predictive coding underlie hallucinations in schizophrenia. J Neurosci. 2014 Jun 11;34(24):8072-82.
Horga G, Maia TV, Wang P, Wang Z, Marsh R, Peterson BS. Adaptation to conflict via context-driven anticipatory signals in the dorsomedial prefrontal cortex. J Neurosci. 2011 Nov 9;31(45):16208-16.
Horga G, Parellada E, Lomeña F, Fernández-Egea E, Mané A, Font M, Falcón C, Konova AB, Pavia J, Ros D, Bernardo M. Differential brain glucose metabolic patterns in antipsychotic-naïve first-episode schizophrenia with and without auditory verbal hallucinations. J Psychiatry Neurosci. 2011 Sep;36(5):312-21.