Alex Dranovsky, MD, PhD

Profile Headshot

Overview

Academic Appointments

  • Florence Irving Assistant Professor of Psychiatry at CUMC

Gender

  • Male

Credentials & Experience

Education & Training

  • State University of New York
  • Residency: New York State Psychiatric Institute
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center

Research

Virtually all mental and some medical illnesses are exacerbated by stress and alleviated by enriching experiences. Such experiences are thought to be causal or protective in cases of schizophrenia, anxiety/affective disorders, and substance abuse. Yet, the mechanisms by which experiences can confer or neutralize genetic risks for mental illness remain elusive. In a longstanding collaboration with David Leonardo, our lab is focused on deciphering how stressful and enriching experiences produce lasting changes in the postnatal brain, and how such changes can predict adaptive and maladaptive behaviors.

One major area of focus is the adult hippocampal stem cells. These stem cells are greatly affected by enriching and stressful experiences, producing more or fewer functional neurons. Thus, they are an ideal model system for studying the molecular, cellular, and circuit substrates for stressful and enriching experiences. Moreover, the hippocampal stem cell system provides a naturalistic setting for unraveling the molecular logic of neural stem cell renewal and differentiation. Through the use of inducible genetic manipulations in mice, in vitro cellular assays, transplantation studies, and behavioral experiments we are exploring the mechanisms by which stressful and enriching experiences instruct stem cells to produce more stem cells or neurons in the adult hippocampus. Given the important role of the hippocampus as a modulator of the HPA axis, we are also examining the contribution of hippocampal stem cells and their progeny to how the animal adapts to stress.

Our second major focus is the mechanisms by which certain postnatal periods are particularly sensitive to the effects of stress and enrichment. Different experiences during such “critical” periods result in especially sustained behavioral phenotypes, but underlying changes in the brain are poorly understood. We are exploring how the hippocampal stem cell system and other circuits can encode experiences during sensitive periods to establish sustained behavioral phenotypes.

Research Interests

  • Models of Psychiatric Disorders
  • Cognitive/Systems Neuroscience
  • Synapses and Circuits
  • Stem Cell Biology
  • Neurobiology of Disease

Grants

ROLE OF DENTATE GRANULE CELL BIRTH DATE IN DETERMINING STRESS-RELATED FUNCTION (Federal Gov)

Sep 1 2017 - Aug 31 2020

EXPLORING THE PATHOPHYSIOLOGY OF ANXIETY: THE ROLE OF THE HIPPOCAMPUS, AMYGDALA AND MEDIAL PREFRONTAL CORTEX (Federal Gov)

Jul 1 2013 - Mar 31 2019

QUIESCENT DCLK1+ STEM CELLS IN THE MOUSE INTESTINE (Federal Gov)

Sep 1 2013 - May 31 2017

TEMPORAL SPECIFICATION OF NEURONAL FUNCTION AND ITS RELEVANCE TO MENTAL HEALTH (Federal Gov)

Jun 20 2016 - Dec 31 2016

ROLE OF NEURONS IN THE DEVELOPMENT AND PROGRESSION OF PANCREATIC CANCER (Private)

Jan 1 2013 - Dec 31 2016

DEVELOPMENTAL REGULATION OF MOOD STATES BY 5-HT1A HETERORECEPTORS (Federal Gov)

Sep 4 2015 - May 31 2016

A LATE SENSITIVE PERIOD FOR THE DEVELOPMENT OF ANXIETY DISORDERS (Federal Gov)

Jul 5 2010 - Feb 29 2016

A LATE SENSITIVE PERIOD FOR THE DEVELOPMENT OF ANXIETY DISORDERS (Federal Gov)

Jul 5 2010 - Feb 28 2015

DISSECTING THE ROLE OF ADULT-BORN HIPPOCAMPAL NEURONS IN ENCODING STRESS (Private)

Jan 15 2013 - Jan 14 2015

MECHANISMS AND SIGNIFICANCE OF NEURAL STEM CELL FATE PLASTICITY IN THE ADULT HIPPOCAMPUS (Federal Gov)

Jul 21 2010 - Dec 31 2014

THE CONTRIBUTION OF ADULT-BORN NEURONS TO HIPPOCAMPAL STRUCT URE AND CONNECTIVITY (Federal Gov)

Jan 1 2007 - Dec 31 2012

EFFECTS OF STRESS AND ANTIDEPRESSANTS ON CELLULAR AND CIRCUIT PLASTICITY OF ADULT-BORN HIPOCAMPAL NEURONS (Private)

Jul 1 2006 - Jun 30 2008

Selected Publications

  • Dranovsky A. and Leonardo E.D. (2011) Is there a role for adult-born neurons in adaptation to stress? Behavioural Brain Research PMID: 21621559.
  • Dranovsky A., Picchini A.M., Moadel T., Yamada A., Kimura S., Leonardo E.D., Hen R. (2011) Experience dictates stem cell fate in the adult hippocampus. Neuron 70(5):908-23.
  • Sahay A., Scobie K., Hill A., O’Carroll C.M., Kheirbek M., Burghardt N., Fenton A., Dranovsky A., Hen R. (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472:466-70
  • Dranovsky A. and R. Hen (2006) Hippocampal neurogenesis: Regulation by stress and antidepressants. Biol. Psychiatry 59, 1136-1143
  • Dranovsky A. and Hen R. (2007) DISC1 puts the brakes on neurogenesis. Cell 130(6), 981-3
  • Richardson-Jones J.W., Craige C.P., Guiard B.P., Stephen A., Metzger K.L., Kung H.F., Gardier A.M., Dranovsky A., David D.J., Beck S.G., Hen R., Leonardo E.D. (2010) 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 65(1): 40-52