Current Studies

Here is a list of some of our current studies. For additional studies, please visit RecruitMe.

  • This research study uses brain imaging to explore the biological causes of major depression and why some people feel suicidal or may act on such thoughts. The investigators hope to develop a better understanding of how people who feel depressed and suicidal cope with their feelings to improve treatment and prevention. Individuals may qualify if they have depression with or without suicidal thoughts or any history of suicide attempts. Participation involves a detailed diagnostic set of interviews, brain imaging scans (MRI and PET) and neuropsychological tasks.
  • In this research study, you will receive a medication called carbidopa/levodopa (Sinemet). This medication is approved by the Food and Drug Administration for the treatment of Parkinson's Disease.We are using carbidopa/levodopa off-label in this study to see whether it is capable of improving depressive symptoms as well as mental and physical slowing that occur as people age.
  • The study is an outpatient treatment study of the safety and benefit of extended-release mixed amphetamine salt (Adderall-XR) in the treatment of individuals with cannabis use disorder and Attention Deficit/Hyperactivity Disorder (ADHD). The study is a 13-week trial and requires participants to come twice per week. The primary objective of the study is to determine the safety and effectiveness of Adderall-XR in decreasing marijuana use and in promoting a decrease in ADHD symptoms.
  • This study proposes to recruit patients with Opioid Use Disorder (OUD) seeking treatment into our program of a 5 day outpatient detoxification and naltrexone induction followed by a relapse-prevention treatment with Extended release-naltrexone (XR-NTX) for 8 weeks.
  • The CDC estimates that 10-20% of patients with Lyme disease will go on to have chronic symptoms despite having had appropriate treatment, a condition known as Post-Treatment Lyme Disease Syndrome (PTLDS). While there is currently no known cure, various therapies are being investigated. One promising approach is the practice of meditation and yoga which have been shown to help pain and fatigue associated with other chronic illnesses as well as to improve overall physical, mental, and emotional health.
  • Children with Attention-Deficit/Hyperactivity Disorder (ADHD) are typically treated with two types of medications: stimulants and non-stimulants. These medications work in different ways to treat ADHD symptoms, but we do not fully understand the brain mechanisms underlying the medications' effects. This study will use MRI scanning to look at changes in the brain associated with medication treatment of ADHD in children.
  • Children with Attention-Deficit/Hyperactivity Disorder (ADHD) are typically treated with two types of medications: stimulants and non-stimulants. These medications work in different ways to treat ADHD symptoms, but we do not fully understand the brain mechanisms underlying the medications' effects. This study will use MRI scanning to look at changes in the brain associated with medication treatment of ADHD in children.
  • The purpose of this research study is to find out which antidepressants work best in individuals over the age of 60 years. We invite you to participate in this research study because you are 60+ years old have depression and your depression has not gotten better even after taking two or more medications.
  • Psilocybin is the active ingredient in some forms of psychedelic mushrooms. Its effects can include euphoria, visual hallucinations, changes in perception, a distorted sense of time and spiritual experiences. Adverse events can include headaches, rapid heart beat, increased blood pressure, nausea and panic attacks. All of these effects generally last minutes to hours, though perceptual changes occasionally recur to a lesser and lesser extent as they dissipate over several weeks.
  • The purpose of this study is to examine the use of a new portable brain imaging device to study a measure of brain activity, and to develop optimal methods for analyzing the data from this device. After baseline assessments including clinical interview, physical exam, and blood tests, participants will undergo 3 brain scans on separate days: two Positron Emission Tomography (PET) scans, each lasting one hour, using different PET cameras, to measure metabolic activity in the brain, and one Magnetic Resonance Imaging (MRI) scan, to obtain information about brain structure.

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