Current Studies

Here is a list of some of our current studies. For additional studies, please visit RecruitMe.

  • This study will test a computer-based behavioral intervention to decrease cocaine use. Those who fail to achieve cocaine abstinence after the first 4 weeks while receiving the behavioral treatment will continue the behavioral treatment and be randomly assigned to one of two groups (one group will receive Adderall-XR (MAS-ER) and the other group will receive placebo (an inactive sugar pill)), over the course of 10 weeks. Patients will be asked to come into the clinic for outpatient treatment 3 times per week.
  • We are seeking adolescents ages 13-17 to participate in a study on anhedonia. Anhedonia is the reduced ability to feel pleasure or enjoy things, and is a key feature of depression and other mental illnesses. If you believe your child is experiencing anhedonia, they may be eligible to participate in this study. If your child participates in this study, we will ask that they answer questions about themselves in an interview with our study team and complete some tasks during an electroencephalogram (EEG) test.
  • The goal of the project is to identify brain signatures associated with obsessive-compulsive disorder (OCD) by comparing brain images of (1) individuals with OCD, (2) individuals without OCD, and (3) siblings of individuals with OCD who do not themselves have the disorder. Eligible participants will be asked questions about their medical and psychiatric history, perform tasks on a computer, and receive a brain scan using Magnetic Resonance Imaging (MRI). The study can be completed in one or two in-person visits.
  • The goal of the project is to identify brain characteristics associated with obsessive-compulsive disorder (OCD) by comparing brain images of (1) individuals with OCD, (2) individuals without OCD, and (3) siblings of individuals with OCD who do not themselves have the disorder. Eligible participants will be asked questions about their medical and psychiatric history, perform tasks on a computer, and receive a brain scan using Magnetic Resonance Imaging (MRI). The study can be completed in one or two in-person visits. This study does not involve treatment.
  • We are trying to understand what causes bipolar disorder and how medications treat bipolar depression. If you participate, you will have two different brain scans (MRI and PET scan). You will also have antidepressant treatment for free. We will then be able to see whether information on the brain scans connects with how people do on the medications. The medications are common, and are not experimental. You will be able to discuss the treatment with Dr. Lan before starting the study to make sure that it is the proper treatment for you.
  • We are trying to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, we are looking at the importance of inflammation in the process. If you participate, you will have genetic testing and three different brain scans (one MRI and two PET scans). You will also receive an experimental medication for your depression named N-acetyl cysteine (NAC). Please contact us if you are interested in participating.
  • Columbia University Medical Center is presently recruiting individuals who have experienced trauma to participate in an fMRI research study. For your participation, you will receive up to $270 and an opportunity to advance research in the area of trauma and PTSD. This study involves two visits.
  • This research study aims to explore learning and memory in children who have not been diagnosed with any neurological or psychiatric disorders. This study will take place at the New York State Psychiatric Institute in the Washington Heights neighborhood of Manhattan. Participation in this study includes three parts: interviews, games and puzzles, and 1-2 MRI scans. Your child will receive compensation up to $325 in the form of a gift card for participating in this study.
  • Principal Investigator

    Ragy Girgis, MD
    Have you or your child ever had unusual thoughts, experiences or feelings, or do you have a family member with schizophrenia or psychosis? If so, you may be eligible for our clinic and research program. Researchers at the New York State Psychiatric Institute are interested in how these experiences may change over time.
  • Principal Investigator

    Ragy Girgis, MD
    Healthy volunteers, age 14-30 years, needed for research study to understand thoughts and feelings young people experience over time. Study requirements: 6-7 hours including interviews, and word tests over the course of 1-2 visits at the Columbia University Medical Center (CUIMC)/New York State Psychiatric Institute (NYSPI) Follow-up interview for 6-7 hours after 2.5 years MRI scan of the brain every 6 months (3 hours).

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