Current Studies

Here is a list of some of our current studies. For additional studies, please visit RecruitMe.

  • Why do some individuals continue to experience chronic symptoms of Lyme Disease, such as pain, fatigue, sensory hypersensitivity, and neurocognitive difficulties long after receiving treatment? Through the use of brain imaging (functional MRI) and specific biomarker testing, we hope to gain a better understanding as to why patients develop this persistent, debilitating pain. Based on prior research, we suspect that Lyme disease may change the pattern of an individual's brain activation, making him or her more sensitive to pain than a healthy person.
  • Are you suffering from chronic fatigue that began after you were diagnosed and treated with antibiotics for Lyme Disease? This new treatment research study investigates whether disulfiram, commonly known as "Antabuse", has the potential to be used as a treatment option for patients experiencing chronic post-treatment Lyme symptoms. This well-known, FDA approved drug is currently used to help individuals with alcohol dependence resist consumption; however, new scientific research has demonstrated that disulfiram is a potent killer of the Lyme bacteria in the laboratory setting.
  • For this study, eligible participants will be asked questions about their symptoms and complete a medical evaluation. You will receive a medication, and be monitored by medical professionals. You will also be asked to complete questionnaires. The purpose of this study is to assess to evaluate a medication for the treatment of OCD.
  • Depression affects 15 million Americans each year. Depression and suicidal behavior are transmitted in families due to a combination of genes and environment. Depressive illness and the risk of suicidal behavior are associated with altered brain function that we can detect with brain imaging. Therefore, this study aims to examine brain function in adults who have a relative who has suffered from depression and made a suicide attempt. The goal of the study is to detect which adult children are at risk of developing depression and who is not going to develop depression.
  • The purpose of this study is to evaluate the efficacy, safety and tolerability of different doses and durations of TV-46000 given by subcutaneous (under the skin) injection as compared to placebo for use as a potential maintenance in adults with schizophrenia.
  • Interpersonal Psychotherapy is an effective treatment for adolescents with depression and for adults with PTSD in a recent study. We aim to investigate the use of Interpersonal Psychotherapy for adolescents suffering from PTSD or elevated PTSD symptoms. Participation includes a thorough diagnostic evaluation and a full course of Interpersonal Psychotherapy for Adolescents (IPT-A; 14-16 weeks). If participants have shown reduced PTSD symptoms, they will also receive 3 months of once a month maintenance treatment. All study procedures will be provided at no cost to you.
  • The purpose of this study is to investigate the relationship between aging processes and PTSD, which may help identify novel therapeutic targets to promote healthier aging trajectories for PTSD patients. Chronic PTSD increases mortality risk from medical diseases, promotes aging-associated syndromes such as frailty, and is linked to faster cognitive decline in older adults. One strong possibility is that PTSD leads to these adverse health outcomes by accelerating biological aging in the brain and body.
  • Principal Investigator

    Ragy Girgis, MD
    We are conducting a study to understand the brains of people with type I diabetes mellitus. We are recruiting both people WITH and WITHOUT type I diabetes between the ages of 13 to 35 to participate in this study at Columbia University Irving Medical Center/New York State Psychiatric Institute. Participation involves: One in-person interview to determine your eligibility (up to 1-2 hours), Urine test for substance use, and Magnetic resonance imaging (MRI) scan of the brain (up to 30 minutes).
  • This 8-week inpatient study seeks to recruit healthy male and female patients who are currently using heroin or non-medically using opioid analgesics. Following screening participants are admitted onto the inpatient unit where they complete testing sessions throughout the inpatient stay. Participants are compensated for each screening visit and for each inpateint day if they enroll in the trial. Total payments will be approximately $6720.
  • The Neurocognition of Language Laboratory is seeking children from 6 12 years of age to participate in a brain study of visual-sensory processing. We will use a technique called electroencephalography (EEG) to measure the brains electrical activity by placing small electrodes that rest on the scalp. EEG is pain-free, safe, and non- invasive. We are looking for children with autism spectrum disorder (ASD) who do not take psychiatric medications and neurotypical children without psychiatric diagnoses.