Clinic for Aging, Anxiety, and Mood Disorders (CAAM)

We are an outpatient research clinic dedicated to improving the lives of people suffering from depression and cognitive impairment. The Clinic for Aging, Anxiety, and Mood Disorders (CAAM) is part of Columbia Psychiatry at Columbia University and is located at the New York State Psychiatric Institute at 1051 Riverside Drive, NY NY, 10032.

Directed by Dr. Patrick J. Brown, the clinical research focuses on the following problems in adults and elderly people:

  • Depression
  • Frailty
  • Mild Cognitive Impairment
  • Post-Traumatic Stress Disorder (PTSD)
  • Motor and Cognitive Slowing
  • Hearing Impairment

Read about our recent findings here.

A study involving older adults with pre-existing major depressive disorder living in Los Angeles, New York, Pittsburgh, and St. Louis found no increase in depression and anxiety during the COVID-19 pandemic. Researchers from five institutions, including Columbia, found that the older adults, who were already enrolled in ongoing studies of treatment resistant depression, also exhibited resilience to the stress of physical distancing and isolation.

Clinical Research

Since 1996, the Clinic for Aging, Anxiety, and Mood Disorders (CAAM), formerly the Adult and Late Life Depression Clinic, has been at the forefront of the study of depression and the treatment of patients who suffer from this illness.

This clinic offers free and confidential out-patient treatment for eligible patients in clinical research studies of standard and new antidepressant medications as well as innovative approaches to the treatment of depression. These studies are funded by the National Institutes of Health, private foundations and the pharmaceutical industry. The studies cover a wide range of depressive illness including mild and severe depression, depression with atypical or classical symptoms, chronic forms of mild depression often referred to as dysthymia, and for patients in late life, depression with memory problems. The initial evaluation, including all laboratory work, is free and for eligible patients all care in research studies and study-related medication are also free. Patients who are evaluated at the clinic receive an extended diagnostic consultation with a psychiatrist and a research social worker/research nurse, plus compensation. Each patient has his or her own unique combination of depressive symptoms and medical conditions; thus, special care and time is taken to determine which research study, if any, is best suited to each patient. If a patient enters a research study, a team of psychiatrists, social workers, nurses, and study coordinators meet with the patient frequently, often on a weekly basis, to monitor the effectiveness and safety of treatment. Once the research study is completed, patients may continue their treatment at the clinic free of charge for a period of at least three months.

Research studies at the clinic are focused on learning more about the psychobiology and treatment of depression through the adult life cycle.