Spiro Pantazatos, PhD

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Dr. Spiro P. Pantazatos is Assistant Professor of Clinical Neurobiology (Psychiatry) at Columbia University. He is also Research Scientist at the New York State Psychiatric Institute.

Research Focus

Dr. Pantazatos has interests and experience in translational neuroinformatics, computational neuroimaging and psychiatric genomics. His work includes development and application of computational tools to accelerate mental health research. A primary research track applies data mining to brain imaging, molecular neuroanatomy and genomics data to identify and understand the etiology of anxiety, mood disorders and suicide in order to help guide treatment development for these disorders.

Dr. Pantazatos is also spearheading development of My Brain and Me, a web interface that will crowdsource brain imaging and behavioral data while allowing participants to explore their own brain. The goal is to create a scalable approach that speeds up neuroimaging and mental health research and also increases public awareness and engagement with neuroscience.

Other ongoing interests include birth season and neurobehavioral traits, political psychology and cognitive neuroscience, intuition and psychoinformatics.

Academic Appointments

  • Assistant Professor of Clinical Neurobiology in Psychiatry


Selected Publications

Lan, M.J., Rizk, M.M., Pantazatos, S.P., Rubin-Falcone, H., Miller, J.M., Sublette, M.E., Oquendo, M.A., Keilp, J.G., Mann, J.J., 2019. Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation. Depress Anxiety 36, 433-441.

Milak, M.S., Pantazatos, S., Rashid, R., Zanderigo, F., DeLorenzo, C., Hesselgrave, N., Ogden, R.T., Oquendo, M.A., Mulhern, S.T., Miller, J.M., Burke, A.K., Parsey, R.V., Mann, J.J., 2018. Higher 5-HT 1A autoreceptor binding as an endophenotype for major depressive disorder identified in high risk offspring - A pilot study. Psychiatry Research: Neuroimaging 276, 15-23.

Zanderigo, F., Pantazatos, S., Rubin-Falcone, H., Ogden, R.T., Chhetry, B.T., Sullivan, G., Oquendo, M., Miller, J.M., Mann, J.J., 2018. In vivo relationship between serotonin 1A receptor binding and gray matter volume in the healthy brain and in major depressive disorder. Brain structure & function.

Pantazatos, S., Huang, Y., Rosoklija, G., Dwork, A., Arango, V., Mann, J., 2017. Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity. Molecular psychiatry 22, 760-773.

Pantazatos, S.P., Li, X., 2017. Commentary: BRAIN NETWORKS. Correlated Gene Expression Supports Synchronous Activity in Brain Networks.Science 348, 1241-4. Frontiers in neuroscience 11, 412-412.

Yin, H., Pantazatos, S.P., Galfalvy, H., Huang, Y.Y., Rosoklija, G.B., Dwork, A.J., Burke, A., Arango, V., Oquendo, M.A., Mann, J.J., 2016. A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics 171, 414-426.

Pantazatos, S.P., Andrews, S.J., Dunning-Broadbent, J., Pang, J., Huang, Y.Y., Arango, V., Nagy, P.L., John Mann, J., 2015. Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in major depression and suicide. Neurobiology of disease 79, 123-134.

Pantazatos, S.P., 2014. Prediction of individual season of birth using MRI. Neuroimage 88, 61-68.

Pantazatos, S.P., Talati, A., Schneier, F.R., Hirsch, J., 2014. Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment. Neuropsychopharmacology 39, 425-434.

Talati, A., Pantazatos, S.P., Schneier, F.R., Weissman, M.M., Hirsch, J., 2013. Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies. Biological psychiatry 73, 75-84.

Pantazatos, S.P., Talati, A., Pavlidis, P., Hirsch, J., 2012a. Decoding unattended fearful faces with whole-brain correlations: an approach to identify condition-dependent large-scale functional connectivity. PLoS computational biology 8, e1002441-e1002441.

Pantazatos, S.P., Talati, A., Pavlidis, P., Hirsch, J., 2012b. Cortical functional connectivity decodes subconscious, task-irrelevant threat-related emotion processing. NeuroImage 61, 1355-1363.

Lai, G., Pantazatos, S.P., Schneider, H., Hirsch, J., 2012. Neural systems for speech and song in autism. Brain 135, 961-975.

Pantazatos, S.P., Li, J., Pavlidis, P., Lussier, Y.A., 2009. Integration of Neuroimaging and Microarray Datasets through Mapping and Model-Theoretic Semantic Decomposition of Unstructured Phenotypes. Cancer Inform 8, 75-94.

For a full list of publications see this link.