Studies for Depression

Adult and Late Life Depression Research Clinic Studies for Depression

Antidepressant Response in Late-Life Depression

In this research study, you may receive treatment for depression with an FDA approved medication called escitalopram (Lexapro) or placebo. Escitalopram is a Selective Serotonin Reuptake Inhibitor (SSRI) medication that appears to help with symptoms of depression by increasing the availability of specific chemicals in the brain. A placebo is a sugar pill. The purpose of this study is to determine how treatment response may change depending on how studies are designed. Participants in this study will also undergo Magnetic Resonance Imaging (MRI) in order to investigate the brain responses associated with depression.

Study Activities

  • Filling Out Forms
  • Blood Samples
  • MRI Scan

Eligibility

  • Ages Eligible for Study: 60 Years - 90 Years
  • Genders Eligible for Study: Both
  • This study is not recruiting Healthy Volunteers.

For more information, please contact Kaleigh O’Boyle at 646-774-8652. Para servicio en Español, contacte a Sandra Sanchez-Ramirez 646-774-8692.

Optimizing Outcomes for Treatment Resistant Depression in Older Adults (OPTIMUM)

The goal of this research study is to identify the most effective medication treatments for older adults with treatment resistant depression. Those who have treatment resistant depression have tried at least two antidepressant medications in the past and are still feeling depressed. Patients will begin in Step 1 of the study, where they will take either Bupropion (Wellbutrin) or Aripiprazole (Abilify) for 10 weeks. If they are not feeling better at the end of this phase, they have the choice to enter Step 2 of the study. During Step 2, they will take either Lithium or Nortriptyline (Pamelor) for another 10 weeks. All medications used in this study are FDA-approved. Patients can choose to be treated by their own doctor or by our clinic psychiatrists.

Study Activities

  • Filling out forms
  • Blood samples
  • Neuropsychological Tests

Eligibility

  • Ages eligible; 60 years and older
  • Genders eligible: Both
  • At least two trials of antidepressant medications
  • This study is not recruiting healthy volunteers

For more information, please call Stephanie Gomez at 646-774-8698. Para servicio en Español, contacte a Sandra Sanchez-Ramirez 646-774-8692.

Developing New Clinical Management Strategies for Antidepressant Treatments

The purpose of this study is to investigate whether individuals who have in-person visits with a doctor once per month respond to treatment differently from individuals who have in-person visits with a doctor once per week. In this research study, you may receive treatment for depression with an FDA approved medication called escitalopram (Lexapro) or placebo. Escitalopram is a Selective Serotonin Reuptake Inhibitor (SSRI) medication that appears to help with symptoms of depression by increasing the availability of specific chemicals in the brain. A placebo is a sugar pill.

Study Activities

  • Filling out forms
  • Blood samples
  • Phone calls and/or doctor visits

Eligibility

  • Ages eligible; 18-75
  • Genders eligible: Both
  • This study is not recruiting healthy volunteers

For more information, please call Stuart Fine at 646-774-8670.