Current Studies

  • The purpose of this study is to investigate the relationship between aging processes and PTSD, which may help identify novel therapeutic targets to promote healthier aging trajectories for PTSD patients. Chronic PTSD increases mortality risk from medical diseases, promotes aging-associated syndromes such as frailty, and is linked to faster cognitive decline in older adults. One strong possibility is that PTSD leads to these adverse health outcomes by accelerating biological aging in the brain and body.
  • Principal Investigator

    Bret R. Rutherford, MD
    The Columbia University Irving Medical Center Department of Psychiatry is conducting a clinical research study at the New York State Psychiatric Institute looking at depression in adults ages 18-75. Participants in this study will be randomly assigned to either treatment with medication or a sugar pill. The medication is called escitalopram and it is an FDA approved medication indicated for the treatment of major depressive disorder. A placebo is a sugar pill.
  • In this research study, you will receive a medication called carbidopa/levodopa (Sinemet). This medication is approved by the Food and Drug Administration for the treatment of Parkinson's Disease.We are using carbidopa/levodopa off-label in this study to see whether it is capable of improving depressive symptoms as well as mental and physical slowing that occur as people age.
  • The purpose of this research study is to find out which antidepressants work best in individuals over the age of 60 years. We invite you to participate in this research study because you are 60+ years old have depression and your depression has not gotten better even after taking two or more medications.
  • In this research study, you will be fitted with hearing aids that may be fully tuned to improve your hearing (full dose) or may be only partially tuned and not likely to substantially improve your hearing (low dose). You will receive a free hearing aid that will be at full dose at the end of the 12 week study. You will also receive treatment for depression with an FDA approved medication called escitalopram (Lexapro) or duloxetine (Cymbalta).