The Brain Stimulation and Therapeutic Modulation (BSTM) Division specializes in the use of emerging electroma gnetic means of modulating brain function to study and treat psychiatric disorders. The ability to stimulate targeted brain structures non- invasively has opened for the first time the potential to probe the circuitry underlying brain-based disorders and represents a powerful new tool for treating disorders that fail to respond to conventional therapies. The BSTM encompasses research programs (preclinical, translational, and clinical) and clinical services utilizing existing and emerging brain stimulation and neuromodulation interventions at NYSPI and NYPH. These techniques include deep brain stimulation (DBS), electroconvulsive therapy (ECT), magnetic seizure therapy (MST), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and vagus nerve stimulation (VNS). These techniques are applied as probes of brain function, as therapeutic interventions, or in conjunction with functional imaging (simultaneous TMS/fMRI, TMS/PET, TMS/MRS). The clinical research facilities include the Brain Behavior Clinic at NYSPI, the Brain Stimulation Service at NYPH, 2 newly constructed human TMS treatment suites at NYSPI, the TMS Unit of the fMRI Center, Stimulation/Imaging facilities (TMS/fMRI, TMS/PET, TMS/MRS), and the ECT suites at NYSPI and NYPH. The pre-clinical research facilities include the Nonhuman Primate Brain Stimulation Lab, the Primate Cognition Lab, and the Brain Stimulation Technology Development Laboratory specializing in novel device design and implementation.